{"id":"W3033322560","doi":"10.1158/0008-5472.can-19-2373","title":"The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Kom op tegen Kanker; Vlaamse Liga Tegen Kanker; Vlaamse regering; Universiteit Gent; Stichting Tegen Kanker; Fonds Wetenschappelijk Onderzoek; European Hematology Association","keywords":"Melanoma; Ectopic expression; Cancer research; Mesenchymal stem cell; Epithelial–mesenchymal transition; Transcription factor; Biology; In vivo; Phenotype; Metastasis; Cancer; Cell biology; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005008479,0.0001243215,0.0003001016,0.00007772998,0.0002338247,0.00008503794,0.0001193671,0.00004420855,0.0001944012],"category_scores_gemma":[0.0001473413,0.00008415637,0.0000526797,0.0003435768,0.0002432377,0.0002293319,0.0000449361,0.0003174716,0.000002957916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001025154,"about_ca_system_score_gemma":0.0007425621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001964665,"about_ca_topic_score_gemma":0.0002997304,"domain_scores_codex":[0.9981723,0.0002740443,0.0002678186,0.000330949,0.0006350874,0.0003198043],"domain_scores_gemma":[0.9989114,0.0001659708,0.00006687982,0.000236813,0.0003730589,0.0002458373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009967696,0.0000847757,0.002744599,0.001117758,0.0001111442,0.000009716632,0.005968814,0.000005249863,0.9380589,0.00006744047,0.001025244,0.0498096],"study_design_scores_gemma":[0.003054144,0.002183706,0.01869143,0.0003496282,0.0002301146,0.00001461506,0.002035158,0.0005687724,0.9482188,0.0001829773,0.02422447,0.0002461578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865438,0.006251711,0.0001271544,0.005349496,0.00008743174,0.001138718,0.0000771397,0.00002311979,0.0004013675],"genre_scores_gemma":[0.9969903,0.001748646,0.0003925471,0.0002636026,0.0001934291,0.0001389292,0.00004206293,0.00002799314,0.000202495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04956344,"threshold_uncertainty_score":0.3431797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1634758341936226,"score_gpt":0.3733494961353122,"score_spread":0.2098736619416896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}