{"id":"W3033322560","doi":"10.1158/0008-5472.can-19-2373","title":"The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Kom op tegen Kanker; Vlaamse Liga Tegen Kanker; Vlaamse regering; Universiteit Gent; Stichting Tegen Kanker; Fonds Wetenschappelijk Onderzoek; European Hematology Association","keywords":"Melanoma; Ectopic expression; Cancer research; Mesenchymal stem cell; Epithelial–mesenchymal transition; Transcription factor; Biology; In vivo; Phenotype; Metastasis; Cancer; Cell biology; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007520409,0.0002334003,0.0001785076,0.0001943884,0.0001500725,0.0001760272,0.00007394997,0.0001236262,0.002455539],"category_scores_gemma":[0.00005887439,0.0001063194,0.0001509014,0.0000910997,0.0001457828,0.00009422529,0.0001331659,0.0004474711,0.0005253352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872105,"about_ca_system_score_gemma":0.0001343176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005173928,"about_ca_topic_score_gemma":0.001078713,"domain_scores_codex":[0.9999286,0.0000112222,0.000003581526,0.00001231292,0.0000252105,0.00001913189],"domain_scores_gemma":[0.9999503,0.000009197096,0.000007494964,0.000005016782,0.00000564665,0.00002235004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000379138,0.0000129731,0.00006872187,0.000009239071,0.000001199239,0.00001620632,0.000002603074,0.00001791803,0.9994913,0.00003033382,0.00002472204,0.0002869201],"study_design_scores_gemma":[0.00001217876,0.0002119069,0.002986463,0.000003223008,0.000005921797,0.0002158574,0.00001421967,0.0007970877,0.9936635,0.00002545691,0.002062581,0.000001482702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925548,0.001224284,0.002571939,0.00009140764,0.00003105101,0.00002229,0.0003128197,0.0001050124,0.003086359],"genre_scores_gemma":[0.9926233,0.0005654909,0.001587335,0.00003710407,0.00001143701,0.00002369353,0.0003961597,0.00002198901,0.004733432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002455539,"threshold_uncertainty_score":0.008214593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1634758341936226,"score_gpt":0.3733494961353122,"score_spread":0.2098736619416896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}