{"id":"W3033326213","doi":"10.1007/s40744-020-00209-4","title":"Safety and Efficacy of Tofacitinib in Patients with Active Psoriatic Arthritis: Interim Analysis of OPAL Balance, an Open-Label, Long-Term Extension Study","year":2020,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada); Toronto Western Hospital; University of Toronto","funders":"National Institute for Health and Care Research; Pfizer","keywords":"Tofacitinib; Medicine; Janus kinase inhibitor; Psoriatic arthritis; Tolerability; Adverse effect; Discontinuation; Internal medicine; Concomitant; Incidence (geometry); Interim analysis; Surgery; Arthritis; Clinical trial; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000657607,0.0001415211,0.0009600864,0.0001070735,0.00004840799,0.000005905119,0.00005805753,0.00005042084,0.00003614019],"category_scores_gemma":[0.00002460415,0.0001048915,0.0000194233,0.0002970385,0.0001328377,0.00008456694,0.00006069164,0.00007804488,2.711412e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006979662,"about_ca_system_score_gemma":0.00001590297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008856034,"about_ca_topic_score_gemma":0.0001385323,"domain_scores_codex":[0.9990458,0.00009450151,0.0003309954,0.0003028379,0.00009845971,0.0001273861],"domain_scores_gemma":[0.9994729,0.00007110828,0.0001563921,0.0001539274,0.00007283389,0.00007288231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01514337,0.003007227,0.8920619,0.0000188879,0.001838484,0.000030333,0.002922577,5.227918e-7,0.00002552911,0.00003858114,6.287023e-7,0.084912],"study_design_scores_gemma":[0.05170653,0.00936245,0.9379799,0.0001667999,0.0002139162,0.000007421394,0.0004063349,0.00002894324,0.00003850759,0.000006574428,0.000003165894,0.00007949165],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974734,0.00155877,0.000006004786,0.00005833817,0.00002274553,0.0007962096,0.0000550454,0.00000753276,0.00002195556],"genre_scores_gemma":[0.9963035,0.003466043,0.00005244389,0.00006088925,0.000001882468,0.00001501073,0.00008979021,0.000009365085,0.000001070488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08483251,"threshold_uncertainty_score":0.4277351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497477952717247,"score_gpt":0.3090752962793566,"score_spread":0.2841005167521841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}