{"id":"W3033340144","doi":"10.1200/jco.2020.38.18_suppl.lba1","title":"Maintenance avelumab + best supportive care (BSC) versus BSC alone after platinum-based first-line (1L) chemotherapy in advanced urothelial carcinoma (UC): JAVELIN Bladder 100 phase III interim analysis.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Avelumab; Metastatic Urothelial Carcinoma; Internal medicine; Interim analysis; Clinical endpoint; Chemotherapy; Hazard ratio; Carboplatin; Regimen; Progression-free survival; Randomization; Chemotherapy regimen; Oncology; Progressive disease; Gastroenterology; Bladder cancer; Randomized controlled trial; Cisplatin; Cancer; Urothelial carcinoma; Nivolumab; Immunotherapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003484455,0.001255887,0.002193253,0.0004448496,0.0004031096,0.001041073,0.001055108,0.001192852,0.005600219],"category_scores_gemma":[0.001965606,0.0006390995,0.002394585,0.0003987373,0.0008035681,0.0009410039,0.0004556174,0.002902383,0.0008086262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000982327,"about_ca_system_score_gemma":0.001466315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007733871,"about_ca_topic_score_gemma":0.002414204,"domain_scores_codex":[0.9992125,0.0004598876,0.00004047283,0.0001030317,0.00004707218,0.0001370152],"domain_scores_gemma":[0.9982938,0.0005282995,0.000437485,0.0001329174,0.0000719605,0.0005355109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9740998,0.006706516,0.001291684,0.0002291269,0.0009156921,0.00001765185,0.00004058552,0.0006115239,0.002463727,0.00006659883,0.001108262,0.01244885],"study_design_scores_gemma":[0.7222411,0.2645447,0.007261701,0.00005728432,0.001607369,0.00006045102,0.00002830074,0.001394108,0.001480852,0.0002517373,0.001048111,0.00002422806],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877921,0.002657773,0.0008066787,0.0005877801,0.0002528137,0.003077524,0.002377656,0.0001429672,0.00230479],"genre_scores_gemma":[0.9891221,0.0009686644,0.001642891,0.0007548472,0.0001410876,0.003097102,0.001916603,0.00003689113,0.002319751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005600219,"threshold_uncertainty_score":0.01873457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09353558699766583,"score_gpt":0.4407492632393891,"score_spread":0.3472136762417233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}