{"id":"W3033369584","doi":"10.1002/mus.26995","title":"Whole blood survival motor neuron protein levels correlate with severity of denervation in spinal muscular atrophy","year":2020,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Portage College","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Cure SMA; Biogen","keywords":"Spinal muscular atrophy; Denervation; Motor neuron; Medicine; Atrophy; Progressive muscular atrophy; Lower motor neuron; Physical medicine and rehabilitation; Amyotrophic lateral sclerosis; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006388528,0.0003485041,0.0002872903,0.0004469316,0.0001846845,0.000294489,0.0002361415,0.0002884312,0.002407721],"category_scores_gemma":[0.001250462,0.0002032246,0.0003379493,0.0002454664,0.000229312,0.0001863704,0.0002432489,0.0002597552,0.0001792745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001736746,"about_ca_system_score_gemma":0.0001461626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008831797,"about_ca_topic_score_gemma":0.00117419,"domain_scores_codex":[0.9998069,0.00006528664,0.000016822,0.00005952404,0.00003072052,0.0000207376],"domain_scores_gemma":[0.9989949,0.0004108361,0.0003440848,0.00006679976,0.00004790149,0.000135583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005470456,0.00002171849,0.9948663,0.00001003694,0.0001791663,0.0000672033,0.00002395527,0.000190872,0.002764938,0.0000103826,0.00002400041,0.001294414],"study_design_scores_gemma":[0.00001093698,0.0003284747,0.9974265,0.000002981808,0.00007754256,0.0003935282,0.0000212203,0.001013613,0.0006460396,0.00002504892,0.00005159314,0.000002696901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999524,0.0001034318,0.0002050954,0.000009651728,0.000001282678,0.000001616008,0.00009184015,0.00000412327,0.00005902322],"genre_scores_gemma":[0.9995159,0.00002444709,0.0001881405,0.000004891102,0.000002459543,0.000002972202,0.0001348694,0.000001472433,0.0001248069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002407721,"threshold_uncertainty_score":0.008054674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03697874503891012,"score_gpt":0.2664837862600767,"score_spread":0.2295050412211666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}