{"id":"W3033383072","doi":"10.1002/anie.202006716","title":"Enantioselective Cobalt‐Catalyzed Intermolecular Hydroacylation of 1,6‐Enynes","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto","keywords":"Hydroacylation; Enantioselective synthesis; Stereocenter; Domino; Chemistry; Cobalt; Catalysis; Stereochemistry; Bond cleavage; Intermolecular force; Combinatorial chemistry; Organic chemistry; Molecule; Aldehyde","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001417871,0.0001826048,0.0002254112,0.00009172888,0.00005192917,0.00003555662,0.0002746089,0.0001299449,0.003692574],"category_scores_gemma":[0.0009230888,0.0002043422,0.0001687317,0.000269931,0.00009599649,0.000333624,0.00009068466,0.0001658629,0.00004407967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001576216,"about_ca_system_score_gemma":0.00007575822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003063607,"about_ca_topic_score_gemma":0.000002618602,"domain_scores_codex":[0.9984124,0.00001869584,0.0004801612,0.000374888,0.0005639664,0.0001499476],"domain_scores_gemma":[0.9986942,0.0001502024,0.0003574083,0.0001791417,0.0005142801,0.0001047596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001804511,0.00008894417,0.000756392,0.00008792443,0.0001790943,0.000005148071,0.0004075619,0.0001446066,0.9911958,0.001304735,0.004552997,0.001096336],"study_design_scores_gemma":[0.0008405254,0.00001815528,0.0003410713,0.00006469226,0.0000550755,0.00001506552,0.0001351144,0.00240742,0.9841889,0.00117992,0.01056662,0.0001874889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2868409,0.0003497336,0.5634481,0.007208257,0.002550002,0.0003978818,0.001078225,0.000600202,0.1375266],"genre_scores_gemma":[0.9934971,0.00004005768,0.001145732,0.0003400897,0.001338179,0.00003318393,0.003235683,0.00003096457,0.0003390114],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7066562,"threshold_uncertainty_score":0.9972182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161452382846266,"score_gpt":0.2769337374391528,"score_spread":0.2553192136106902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}