{"id":"W3033397665","doi":"","title":"Inhibiting ULK1 kinase decreases autophagy and cell viability in high-grade serous ovarian cancer spheroids.","year":2020,"lang":"en","type":"article","venue":"PubMed","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ovarian Cancer Canada; Western University","funders":"","keywords":"Autophagy; Cancer research; ULK1; Ovarian cancer; Gene knockdown; Spheroid; Viability assay; Chemistry; Cancer cell; Biology; Kinase; Cell biology; Protein kinase A; Cell; Cancer; Medicine; Cell culture; Internal medicine; Apoptosis; AMPK; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100993,0.0001626779,0.0002350063,0.0002010667,0.0001448577,0.0002026628,0.00006827368,0.0001250733,0.0008390053],"category_scores_gemma":[0.0001185098,0.00007804611,0.0001432302,0.0002169868,0.0001471086,0.0001389139,0.0001092556,0.0002891107,0.0002058904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237696,"about_ca_system_score_gemma":0.0002020795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222201,"about_ca_topic_score_gemma":0.002480068,"domain_scores_codex":[0.9999106,0.00001913816,0.00001230105,0.00001502538,0.00002390272,0.00001898022],"domain_scores_gemma":[0.999908,0.00002963422,0.00002197696,0.00001108222,0.000009145141,0.00002015877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003207593,0.00004732359,0.001260406,0.0000878815,0.00001640801,0.00007374115,0.00005639411,0.0002086319,0.9936461,0.00005731367,0.0003412392,0.003883607],"study_design_scores_gemma":[0.00002783934,0.0006018857,0.01911983,0.000007814502,0.00002730861,0.0004216488,0.0000908828,0.001393035,0.975008,0.00003699266,0.003258881,0.000005808447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932908,0.002854374,0.001212475,0.0001249623,0.00003626879,0.00002595922,0.001017748,0.0001157127,0.001321679],"genre_scores_gemma":[0.9953492,0.0008970995,0.001476497,0.00002947149,0.00000638853,0.00002464529,0.0009861412,0.00001194328,0.001218551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222201,"threshold_uncertainty_score":0.002806723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075740933910226,"score_gpt":0.2401637605744529,"score_spread":0.2194063512353507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}