{"id":"W3033430448","doi":"10.1101/2020.06.05.135392","title":"Characterization of mitochondrial health from human peripheral blood mononuclear cells to cerebral organoids derived from induced pluripotent stem cells","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; University of Toronto; National Alliance for Research on Schizophrenia and Depression; Brain and Behavior Research Foundation","keywords":"Induced pluripotent stem cell; Peripheral blood mononuclear cell; Organoid; Mitochondrion; Human brain; Stem cell; Biology; Cell biology; Neuroscience; Human Induced Pluripotent Stem Cells; Medicine; Immunology; In vitro; Genetics; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003978041,0.0002494967,0.000198564,0.0002202718,0.0001595948,0.0004595718,0.0001461393,0.0002379584,0.001613628],"category_scores_gemma":[0.0002237244,0.00007532941,0.0001881744,0.0002423703,0.0002238774,0.0001137504,0.0002218866,0.0004896713,0.0006950486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515249,"about_ca_system_score_gemma":0.0002023743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008624081,"about_ca_topic_score_gemma":0.0009207074,"domain_scores_codex":[0.999846,0.00002991923,0.00001723148,0.00004860699,0.00004502933,0.0000131544],"domain_scores_gemma":[0.9998486,0.00003761996,0.00002500274,0.00002559794,0.00003883333,0.00002421159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006270276,0.00001074189,0.0005651963,0.00003672785,0.000006239808,0.00008172189,0.00006329732,0.0001140998,0.9965678,0.0001005912,0.0001218396,0.002268889],"study_design_scores_gemma":[0.00001142806,0.0001628789,0.004631082,0.00001706389,0.00002902958,0.0002871902,0.00009771527,0.0005670225,0.985966,0.0001232797,0.008101149,0.000006201148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8633977,0.005308955,0.1161749,0.0006382988,0.0001957257,0.0004033343,0.006549099,0.0005342418,0.006797641],"genre_scores_gemma":[0.9489303,0.001945258,0.03438314,0.0003348405,0.00003069727,0.0002945397,0.00737736,0.0001114959,0.006592329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613628,"threshold_uncertainty_score":0.005398095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601111902908045,"score_gpt":0.2160154905253298,"score_spread":0.2000043714962493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}