{"id":"W3033464992","doi":"10.1016/j.biopha.2020.110330","title":"Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells","year":2020,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Astellas Foundation for Research on Metabolic Disorders; Fujifilm Corporation; Nippon Shinyaku; Bristol-Myers Squibb; Takeda Pharmaceutical Company; Eisai Canada; Japan Agency for Medical Research and Development; Otsuka Pharmaceutical; Astellas Pharma US","keywords":"Staurosporine; Proteolysis; Fusion protein; Caspase; Biology; Cell biology; Caspase 3; Apoptosis; Cell culture; Programmed cell death; Chemistry; Molecular biology; Biochemistry; Signal transduction; Protein kinase C; Genetics; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003339119,0.0002186565,0.0002518064,0.00008901957,0.00006063874,0.00001446853,0.000181929,0.0001175264,0.00007063989],"category_scores_gemma":[0.00002662394,0.0001532706,0.00004588784,0.0002611819,0.0001707257,0.00001016144,0.0001248864,0.0001611962,0.000001494196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002279857,"about_ca_system_score_gemma":0.00006953136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002667783,"about_ca_topic_score_gemma":0.00001705324,"domain_scores_codex":[0.9986069,0.0001230121,0.0003658828,0.0004156218,0.000276081,0.0002125239],"domain_scores_gemma":[0.9993666,0.00001358434,0.0001827008,0.0002187787,0.00005934847,0.0001589652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003694711,0.00005933901,0.0005355299,0.0000597467,0.0000444453,0.000002968516,0.0004782041,0.000005180817,0.9808423,0.000004890915,0.0009959615,0.01660195],"study_design_scores_gemma":[0.002543161,0.0007300345,0.0005778969,0.00003992322,0.00002768224,0.000004129909,0.0001256268,0.0002777658,0.9613193,0.000007662483,0.03418375,0.0001631299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905643,0.002726932,0.0002609458,0.004953669,0.00009754614,0.001311877,0.00002540035,0.00001558761,0.00004369579],"genre_scores_gemma":[0.9916425,0.005168514,0.0003316807,0.002284313,0.0002986878,0.000102058,0.00004386463,0.00003039314,0.00009797972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03318779,"threshold_uncertainty_score":0.6250194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828235120511311,"score_gpt":0.2755726182492305,"score_spread":0.2572902670441173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}