{"id":"W3033464992","doi":"10.1016/j.biopha.2020.110330","title":"Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells","year":2020,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Astellas Foundation for Research on Metabolic Disorders; Fujifilm Corporation; Nippon Shinyaku; Bristol-Myers Squibb; Takeda Pharmaceutical Company; Eisai Canada; Japan Agency for Medical Research and Development; Otsuka Pharmaceutical; Astellas Pharma US","keywords":"Staurosporine; Proteolysis; Fusion protein; Caspase; Biology; Cell biology; Caspase 3; Apoptosis; Cell culture; Programmed cell death; Chemistry; Molecular biology; Biochemistry; Signal transduction; Protein kinase C; Genetics; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316741,0.0003438313,0.0003823134,0.0003489614,0.0001253262,0.0001588222,0.0001795901,0.0001938792,0.0009971129],"category_scores_gemma":[0.00009737143,0.0001253619,0.0003018971,0.0003747926,0.0001104705,0.0001202899,0.0001130193,0.0004149351,0.0002644755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251756,"about_ca_system_score_gemma":0.0002360332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131169,"about_ca_topic_score_gemma":0.003310284,"domain_scores_codex":[0.9998661,0.00002153654,0.00002264278,0.00002089506,0.00003667019,0.00003203208],"domain_scores_gemma":[0.9999279,0.00001858638,0.00001696846,0.00001100405,0.00001048329,0.00001510227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001195231,0.00008301997,0.0002056399,0.00003980721,0.000007467572,0.00004287046,0.000009236553,0.00009230447,0.9976326,0.00003410627,0.00007529124,0.001658076],"study_design_scores_gemma":[0.00003517172,0.0008104249,0.005328973,0.000003928907,0.00001622439,0.000195475,0.00001021816,0.0004436184,0.990965,0.00001773489,0.002170116,0.000003051199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915829,0.003136744,0.001569823,0.0000797514,0.00002710847,0.00009381395,0.001374404,0.00008695848,0.002048456],"genre_scores_gemma":[0.9874736,0.002367525,0.002939445,0.00006891395,0.00001274241,0.0001044435,0.003521901,0.00001550245,0.003495888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001131169,"threshold_uncertainty_score":0.003335714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828235120511311,"score_gpt":0.2755726182492305,"score_spread":0.2572902670441173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}