{"id":"W3033540087","doi":"10.1128/jvi.01112-20","title":"Fusion of Large Polypeptides to Human Adenovirus Type 5 Capsid Protein IX Can Compromise Virion Stability and DNA Packaging Capacity","year":2020,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Capsid; Biology; DNA; Fusion protein; Adenoviridae; Virology; Cell biology; Protein stability; Virus; Genetics; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003716016,0.0002656628,0.0002094435,0.0001318118,0.0001855307,0.0003995832,0.0001762404,0.0003317856,0.0005282172],"category_scores_gemma":[0.0004078294,0.0001577732,0.0002254613,0.0001123089,0.0002677653,0.0003470734,0.0002975105,0.0003972231,0.0001659384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003704378,"about_ca_system_score_gemma":0.000188436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003558561,"about_ca_topic_score_gemma":0.000277522,"domain_scores_codex":[0.9997398,0.0000675711,0.0000324202,0.00004232784,0.000062635,0.00005517218],"domain_scores_gemma":[0.9997733,0.0000975261,0.00005031386,0.00002778595,0.00001559068,0.00003542052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005876584,0.00001029736,0.0001028089,0.00001673629,0.000006291863,0.00002158722,0.00001747555,0.0001125858,0.9990203,0.0001165826,0.00001671308,0.0004998494],"study_design_scores_gemma":[0.000005603577,0.00021134,0.0009033028,0.000003582526,0.0000176916,0.000110188,0.00001761755,0.0007687697,0.99679,0.00004611943,0.001121582,0.000004205235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963583,0.000667861,0.002225044,0.00004187768,0.00001473936,0.00001417439,0.00003608274,0.00003073112,0.0006110513],"genre_scores_gemma":[0.9975355,0.0003102027,0.001273202,0.00002810373,0.000003843793,0.00001223906,0.0001359639,0.0000148469,0.0006861967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005282172,"threshold_uncertainty_score":0.002687752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03724302676964258,"score_gpt":0.3067557996453202,"score_spread":0.2695127728756777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}