{"id":"W3033542474","doi":"10.1167/tvst.9.7.2","title":"Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium","year":2020,"lang":"en","type":"review","venue":"Translational Vision Science & Technology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Hospital for Sick Children","funders":"Spark Therapeutics; ProQR Therapeutics; Biogen; Strong; National Eye Institute; Astellas Pharma; Medical Research Council; NightstaRx; Allergan; Research to Prevent Blindness","keywords":"Clinical trial; Medicine; Retinal; Ophthalmology; Optometry; Bioinformatics; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08396669,0.002190741,0.004330388,0.005022651,0.001489597,0.007492227,0.005062483,0.01819482,0.006342689],"category_scores_gemma":[0.06870861,0.001212491,0.005645781,0.003929606,0.003826664,0.01035508,0.005300917,0.02540178,0.007514965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0068294,"about_ca_system_score_gemma":0.03057124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005048994,"about_ca_topic_score_gemma":0.01128696,"domain_scores_codex":[0.9763615,0.0118002,0.004824642,0.001059656,0.004847261,0.001106774],"domain_scores_gemma":[0.9120913,0.04719021,0.007756542,0.002482271,0.0233638,0.007115923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003501698,0.0001120975,0.0001525869,0.01151276,0.000176789,0.0001998946,0.0002447851,0.0002131649,0.0003277849,0.01282401,0.6815201,0.2923658],"study_design_scores_gemma":[0.0001764599,0.00008600725,0.0002831722,0.02153322,0.0001904184,0.0001702031,0.00008262485,0.00006273849,0.00006287805,0.004825098,0.9724936,0.00003358063],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001232883,0.6407872,0.002559043,0.2967354,0.05441211,0.0004420246,0.0003531924,0.0002106947,0.00437691],"genre_scores_gemma":[0.001536022,0.6557273,0.0164401,0.2938716,0.02244437,0.001402017,0.000548321,0.0001257522,0.007904513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.08396669,"threshold_uncertainty_score":0.4440636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08461442438624929,"score_gpt":0.4529343956312119,"score_spread":0.3683199712449626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}