{"id":"W3033583915","doi":"10.1242/jcs.244657","title":"Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in <i>S. cerevisiae</i>","year":2020,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"H2020 European Research Council; Natural Sciences and Engineering Research Council of Canada; Israel Science Foundation; Michael Smith Health Research BC","keywords":"Stress granule; Biology; Fluorescence recovery after photobleaching; Compartmentalization (fire protection); Yeast; Cell biology; Poly(A)-binding protein; Heat shock protein; Saccharomyces cerevisiae; Intrinsically disordered proteins; Biophysics; Translation (biology); Messenger RNA; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008355489,0.00006470268,0.0001946982,0.000115085,0.00005994142,0.00003708036,0.0005957423,0.00002285511,0.000003695009],"category_scores_gemma":[0.0004170644,0.00003966334,0.0001181634,0.001104523,0.000143018,0.000008614261,0.0001312165,0.0001076637,7.654944e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000174789,"about_ca_system_score_gemma":0.000169876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001770191,"about_ca_topic_score_gemma":0.00003261874,"domain_scores_codex":[0.9988732,0.00008862445,0.0003227943,0.0001638448,0.0003616784,0.0001898926],"domain_scores_gemma":[0.9992552,0.00002260845,0.0001956234,0.0001862404,0.0001640486,0.0001762476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008150652,0.00004133088,0.008357928,0.00001168949,0.00002066772,0.000003728674,0.0001437055,0.0009396384,0.9893031,0.00001773219,0.0001961229,0.0008828264],"study_design_scores_gemma":[0.0003548953,0.0007180578,0.01675242,0.00004821489,0.00004260357,0.000003282943,0.0002137877,0.0002637592,0.9798771,0.00003595855,0.001598885,0.00009110367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949427,0.0002394837,0.0009443893,0.003226695,0.0000146967,0.0002630619,0.000004286699,7.711866e-7,0.0003638798],"genre_scores_gemma":[0.998363,0.0003388656,0.0009518131,0.0002070352,0.000044895,0.000005998343,6.53394e-7,0.000003119069,0.00008459741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009426094,"threshold_uncertainty_score":0.1617424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02799600801719187,"score_gpt":0.3009011710876582,"score_spread":0.2729051630704664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}