{"id":"W3033585191","doi":"10.1093/ndt/gfaa140.mo019","title":"MO019AURORA PHASE 3 TRIAL DEMONSTRATES VOCLOSPORIN STATISTICAL SUPERIORITY OVER STANDARD OF CARE IN LUPUS NEPHRITIS (LN)","year":2020,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Medicine; Clinical endpoint; Urology; Lupus nephritis; Statistical significance; Placebo; Internal medicine; Calcineurin; Surrogate endpoint; Mycophenolate; Renal function; Randomized controlled trial; Phases of clinical research; Pharmacology; Clinical trial; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002164256,0.000522311,0.001748071,0.0003139994,0.0002716714,0.001049801,0.0004952989,0.001023148,0.005921718],"category_scores_gemma":[0.00155353,0.0001769222,0.001330005,0.0002970777,0.0005698574,0.0004727456,0.000262532,0.001830843,0.0006587025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000404219,"about_ca_system_score_gemma":0.0005802626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006045345,"about_ca_topic_score_gemma":0.001687127,"domain_scores_codex":[0.9990456,0.0005753809,0.00005022491,0.0001268273,0.0001059132,0.0000960516],"domain_scores_gemma":[0.9990059,0.000322155,0.000286738,0.00006091339,0.00005246092,0.0002717874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8287651,0.004487385,0.003636812,0.001635105,0.002992952,0.0001264545,0.00006172559,0.0007021463,0.01091663,0.0004132179,0.005817587,0.140445],"study_design_scores_gemma":[0.8082747,0.1609571,0.02018658,0.0002069534,0.001224439,0.0003341467,0.00004249529,0.001024931,0.001363616,0.0003333252,0.006017159,0.00003454458],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9541721,0.03170137,0.0009211056,0.001590643,0.000544506,0.001010432,0.002018286,0.0004521122,0.007589326],"genre_scores_gemma":[0.9899238,0.003611735,0.00111515,0.001026734,0.0005790675,0.0004350653,0.001196946,0.00002201336,0.002089457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005921718,"threshold_uncertainty_score":0.01981014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01917002358898359,"score_gpt":0.3180882710281384,"score_spread":0.2989182474391548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}