{"id":"W3033597903","doi":"10.1158/1535-7163.mct-20-0094","title":"Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Terry Fox Research Institute; University Health Network; Ontario Institute for Cancer Research; BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Pancreas Centre (Canada)","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Genome British Columbia; Canada Foundation for Innovation","keywords":"Biology; Immunogenicity; Pancreatic cancer; Endogenous retrovirus; Cancer; Cancer research; Epigenetics; Colorectal cancer; Epigenomics; Breast cancer; Molecular mimicry; Immunology; Gene; DNA methylation; Gene expression; Genetics; Antibody; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872298,0.0001150373,0.0002161064,0.0006287804,0.0001555691,0.0004422315,0.0001304961,0.000203802,0.001351064],"category_scores_gemma":[0.0006280156,0.00009997044,0.0001515506,0.0004299386,0.0001808002,0.000127556,0.0002558264,0.0002395715,0.0001629493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001446239,"about_ca_system_score_gemma":0.00007905877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003609815,"about_ca_topic_score_gemma":0.0004840405,"domain_scores_codex":[0.9998239,0.00002546808,0.00001865432,0.0000587129,0.00003848603,0.00003478442],"domain_scores_gemma":[0.9995686,0.0001024403,0.0001764433,0.00003944653,0.00004753669,0.00006550218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001191318,0.00005011465,0.7528413,0.00004588773,0.0001098881,0.0005186392,0.0001370901,0.0003429254,0.2384768,0.0001338668,0.0001287547,0.006023298],"study_design_scores_gemma":[0.00001117469,0.0002012113,0.9839334,0.000005483832,0.00004934164,0.001648022,0.0002047652,0.0009245283,0.01241749,0.0001583733,0.0004396953,0.00000649868],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991241,0.0001382226,0.000246274,0.00001106226,0.000001584417,0.00000371335,0.0002795695,0.000007248598,0.0001882509],"genre_scores_gemma":[0.9993423,0.00004493828,0.0001556643,0.000007428799,0.000002347374,0.000005161388,0.0003160032,0.000003496176,0.0001226872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351064,"threshold_uncertainty_score":0.004519761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.061660860817377,"score_gpt":0.2671429476222009,"score_spread":0.2054820868048239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}