{"id":"W3033634500","doi":"10.1093/jnci/djaa082","title":"The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32","year":2020,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Juravinski Cancer Centre; Hôpital de l'Enfant-Jésus; Health Sciences North; Interior Health; BC Cancer Agency; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; University Health Network; Hamilton Health Sciences; Statistics Canada; University of Toronto; Western University; Queen's University","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; Breast Cancer Research Foundation; Pfizer; Genentech; AstraZeneca; Eli Lilly and Company; MacroGenics","keywords":"Metformin; Placebo; Hormone; Internal medicine; Medicine; Oncology; Placebo group; Cancer; Group (periodic table); Endocrinology; Chemistry; Alternative medicine; Insulin; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0045651,0.0009192502,0.002376279,0.0006952245,0.0008924922,0.000936558,0.0008589162,0.001327919,0.004756001],"category_scores_gemma":[0.01233323,0.0003613555,0.002644887,0.001043605,0.000463681,0.000540227,0.0004786585,0.001320054,0.0002523878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006019777,"about_ca_system_score_gemma":0.01139911,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1348588,"about_ca_topic_score_gemma":0.3015392,"domain_scores_codex":[0.9968438,0.001923959,0.0002470489,0.0002512564,0.0004068551,0.0003270308],"domain_scores_gemma":[0.996465,0.001100783,0.001134293,0.0001473185,0.0004414103,0.000711226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8925026,0.0009096824,0.01157803,0.002581757,0.005203826,0.0000600431,0.0001245358,0.000508657,0.001002366,0.0004501818,0.007674202,0.07740402],"study_design_scores_gemma":[0.7477905,0.06107833,0.1618309,0.001306636,0.009291335,0.0001822956,0.0001712565,0.001904852,0.0005405431,0.000696581,0.01509812,0.0001085266],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8248143,0.1473857,0.0004339256,0.005980903,0.0007203652,0.003742977,0.00545423,0.0001106275,0.0113571],"genre_scores_gemma":[0.9796844,0.01133663,0.001106155,0.001560423,0.0003482589,0.002337312,0.001755293,0.00001808194,0.001853515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8651412,"threshold_uncertainty_score":0.2681478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03947836231739529,"score_gpt":0.334283867675105,"score_spread":0.2948055053577097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}