{"id":"W3033657664","doi":"10.1093/ndt/gfaa139.so078","title":"SO078APABETALONE, A BROMODOMAIN AND EXTRA-TERMINAL (BET) PROTEIN INHIBITOR, REDUCES ALKALINE PHOSPHATASE IN CVD PATIENTS, IN MICE, AND IN CELL CULTURE SYSTEMS","year":2020,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Medicine; Alkaline phosphatase; Internal medicine; Placebo; Endocrinology; Bromodomain; Immunology; Pathology; Epigenetics; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618909,0.0001719474,0.0002511777,0.0001057235,0.00002566166,0.00002255696,0.00009134011,0.0003040665,0.000002830213],"category_scores_gemma":[0.0000229476,0.0001658104,0.00003482386,0.000222404,0.0001120193,0.00001351411,0.00003097628,0.0002099051,0.000001737845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001172979,"about_ca_system_score_gemma":0.00003059782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002340135,"about_ca_topic_score_gemma":0.0006251643,"domain_scores_codex":[0.9985796,0.0002120681,0.0003265975,0.0004974568,0.0001215211,0.0002627597],"domain_scores_gemma":[0.9997166,0.0000130876,0.00006039215,0.00008121394,0.00002674616,0.0001019561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00108717,0.0001652846,0.01057256,0.0002212122,0.00001527532,0.00008098805,0.0004977108,0.00003599759,0.9867764,0.000008111881,0.0000553421,0.0004840191],"study_design_scores_gemma":[0.005831954,0.00061703,0.01753755,0.00007558685,0.00004975498,0.0000170203,0.0001153306,0.0005870725,0.9742568,0.00002484085,0.0005830393,0.0003040621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968989,0.002187171,0.00006976314,0.000200456,0.00001364509,0.0005136012,0.00008064695,0.000005256533,0.00003058966],"genre_scores_gemma":[0.9967851,0.001312494,0.0001702696,0.0002634994,0.00004916357,0.0001016185,0.001290092,0.00001317137,0.00001461096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01251957,"threshold_uncertainty_score":0.6761554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006449592300994059,"score_gpt":0.2223788762673521,"score_spread":0.215929283966358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}