{"id":"W3033657664","doi":"10.1093/ndt/gfaa139.so078","title":"SO078APABETALONE, A BROMODOMAIN AND EXTRA-TERMINAL (BET) PROTEIN INHIBITOR, REDUCES ALKALINE PHOSPHATASE IN CVD PATIENTS, IN MICE, AND IN CELL CULTURE SYSTEMS","year":2020,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Medicine; Alkaline phosphatase; Internal medicine; Placebo; Endocrinology; Bromodomain; Immunology; Pathology; Epigenetics; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002664977,0.0004934093,0.0003333642,0.000359919,0.0001012963,0.0003071659,0.000208843,0.000273282,0.002011886],"category_scores_gemma":[0.000139778,0.0001640621,0.0003387028,0.0001582421,0.0001846769,0.0001686579,0.0001056313,0.0008423541,0.0004046203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001576661,"about_ca_system_score_gemma":0.0002286372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004703565,"about_ca_topic_score_gemma":0.00120937,"domain_scores_codex":[0.999821,0.00004499219,0.00001348149,0.00003311466,0.00005475301,0.00003272525],"domain_scores_gemma":[0.9998634,0.00002116584,0.00004006127,0.00001314771,0.00001561195,0.00004664154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002345934,0.0004212513,0.0004948694,0.00009714094,0.00003763466,0.00002961459,0.00001440102,0.0000904051,0.9881846,0.00004501574,0.0002773817,0.007961797],"study_design_scores_gemma":[0.001195068,0.01951721,0.01541274,0.0000245592,0.0001322382,0.0004401174,0.00005335528,0.001363178,0.955228,0.00008169172,0.006538343,0.00001349876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870057,0.006041047,0.002691804,0.0002502966,0.000102067,0.00007497536,0.0009704083,0.0002517632,0.002612013],"genre_scores_gemma":[0.9870576,0.00315215,0.002487766,0.0001452777,0.00003593891,0.0001226566,0.001566283,0.00003609306,0.005396194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002011886,"threshold_uncertainty_score":0.006730437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006449592300994059,"score_gpt":0.2223788762673521,"score_spread":0.215929283966358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}