{"id":"W3033664814","doi":"10.3390/v12060617","title":"Next-Generation Sequencing for HIV Drug Resistance Testing: Laboratory, Clinical, and Implementation Considerations","year":2020,"lang":"en","type":"review","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; Consejo Nacional de Ciencia y Tecnología; Public Health Agency; Public Health Agency of Canada","keywords":"Genotyping; HIV drug resistance; Sanger sequencing; Massive parallel sequencing; Computer science; Medicine; DNA sequencing; Human immunodeficiency virus (HIV); Viral load; Biology; Virology; Antiretroviral therapy; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003211095,0.0003063274,0.001022985,0.0001076941,0.0002479395,0.0001262206,0.00003739511,0.0001146738,0.00004672623],"category_scores_gemma":[0.0006752707,0.0002525697,0.0001288595,0.0002319423,0.0000639112,0.0001528411,0.00002683634,0.0001565628,0.00004364688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001535766,"about_ca_system_score_gemma":0.001757169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004775815,"about_ca_topic_score_gemma":0.0001513063,"domain_scores_codex":[0.9981405,0.0001420178,0.0008965043,0.0004864548,0.0001560916,0.0001784812],"domain_scores_gemma":[0.9983388,0.0007740188,0.0003573018,0.0001921494,0.0001902209,0.0001475512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003387356,0.0001424329,0.001409438,0.01451427,0.001289629,0.0001405222,0.0008740362,1.851588e-7,0.0001761659,0.002530519,0.4858,0.4930889],"study_design_scores_gemma":[0.0007508077,0.00002908863,0.000005197388,0.00206419,0.001428287,0.000009521464,0.00009763104,0.00001400884,0.0001073435,0.00005153223,0.9952235,0.0002189179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000993724,0.9950184,0.00009572146,0.00178471,0.0001677377,0.002259428,0.0003577831,0.0001088852,0.0001079275],"genre_scores_gemma":[0.00003289385,0.9653371,0.0307399,0.0007362677,0.000609104,0.0005343416,0.0007755024,0.00005908251,0.001175796],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5094235,"threshold_uncertainty_score":0.9999927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3540496157979925,"score_gpt":0.444950236739678,"score_spread":0.0909006209416855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}