{"id":"W3033664814","doi":"10.3390/v12060617","title":"Next-Generation Sequencing for HIV Drug Resistance Testing: Laboratory, Clinical, and Implementation Considerations","year":2020,"lang":"en","type":"review","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; Consejo Nacional de Ciencia y Tecnología; Public Health Agency; Public Health Agency of Canada","keywords":"Genotyping; HIV drug resistance; Sanger sequencing; Massive parallel sequencing; Computer science; Medicine; DNA sequencing; Human immunodeficiency virus (HIV); Viral load; Biology; Virology; Antiretroviral therapy; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0468482,0.0005653481,0.0006215622,0.001194703,0.0006119506,0.003574868,0.002050866,0.002911944,0.00457525],"category_scores_gemma":[0.02763446,0.0003165148,0.0005195272,0.0009662248,0.001814694,0.003005674,0.00150911,0.003226004,0.001365039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001937157,"about_ca_system_score_gemma":0.007933335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004389837,"about_ca_topic_score_gemma":0.007748909,"domain_scores_codex":[0.9839454,0.009901146,0.0007465232,0.0009439503,0.003988552,0.0004744986],"domain_scores_gemma":[0.9764665,0.01348411,0.001721435,0.0008990454,0.005890376,0.001538579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003004754,0.0002690179,0.01099579,0.002226724,0.00008548998,0.0004968338,0.0005212939,0.004431235,0.01451,0.0499149,0.04533514,0.870913],"study_design_scores_gemma":[0.0001617839,0.001966444,0.01964714,0.007676539,0.0002091927,0.004787863,0.001667056,0.03211951,0.02339745,0.1158442,0.7922777,0.0002450655],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.02632589,0.1707304,0.291477,0.4582847,0.004003897,0.001391578,0.0009564411,0.001418262,0.04541174],"genre_scores_gemma":[0.1756939,0.1503925,0.6052492,0.05537124,0.004122947,0.001193504,0.001391314,0.000348071,0.006237481],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0468482,"threshold_uncertainty_score":0.2477599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3540496157979925,"score_gpt":0.444950236739678,"score_spread":0.0909006209416855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}