{"id":"W3033665259","doi":"10.1074/jbc.ra120.013029","title":"Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Howard Hughes Medical Institute; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Staphylococcus aureus; Methicillin-resistant Staphylococcus aureus; Microbiology; Medicine; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441189,0.000185961,0.0001467268,0.00007936651,0.0001654744,0.0002057585,0.000339683,0.0002297237,0.00339512],"category_scores_gemma":[0.0002533123,0.00006728504,0.0002767029,0.00006309037,0.0001694004,0.0001493531,0.00009557891,0.0006173053,0.0003305244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003187936,"about_ca_system_score_gemma":0.0002770284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009768007,"about_ca_topic_score_gemma":0.001665607,"domain_scores_codex":[0.9999361,0.0000172957,0.000003811475,0.000008580367,0.0000195489,0.00001466861],"domain_scores_gemma":[0.9998963,0.00003548462,0.00001934883,0.000008467247,0.00001518277,0.00002532998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004610147,0.00009106218,0.001165266,0.0001059457,0.00001748694,0.000534884,0.00007675522,0.0009883788,0.9908833,0.001586034,0.0002223979,0.003867545],"study_design_scores_gemma":[0.0001075853,0.0008030401,0.01585703,0.00003036089,0.00003400738,0.00135244,0.0002529832,0.009980275,0.9596896,0.0009613213,0.01090289,0.00002856099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929278,0.0007136334,0.003550269,0.0004489728,0.00006111215,0.00002626672,0.0001850085,0.000051996,0.002034924],"genre_scores_gemma":[0.9966342,0.0002089826,0.00166327,0.0001040128,0.000007177496,0.000006479913,0.0003158262,0.000008486226,0.001051732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00339512,"threshold_uncertainty_score":0.01135778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03325092564737236,"score_gpt":0.2783735897483162,"score_spread":0.2451226641009438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}