{"id":"W3033719574","doi":"10.1200/jco.2020.38.18_suppl.lba2","title":"A randomized phase III trial of systemic therapy plus early local therapy versus systemic therapy alone in women with de novo stage IV breast cancer: A trial of the ECOG-ACRIN Research Group (E2108).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Randomized controlled trial; Systemic therapy; Clinical endpoint; Hazard ratio; Breast cancer; Cumulative incidence; Internal medicine; Proportional hazards model; Log-rank test; Cancer; Surgery; Oncology; Confidence interval; Cohort","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007061326,0.000299693,0.002924719,0.0001048237,0.000069154,0.00001322413,0.0006589532,0.0004614563,0.00003002338],"category_scores_gemma":[0.0005899563,0.0001675445,0.0006089481,0.0003545963,0.001048146,0.0000159983,0.0001132858,0.0008163849,5.948087e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004348304,"about_ca_system_score_gemma":0.003565007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000587825,"about_ca_topic_score_gemma":0.0001468832,"domain_scores_codex":[0.9913021,0.004424013,0.002696677,0.0004032705,0.0006722889,0.0005017018],"domain_scores_gemma":[0.9945931,0.001847342,0.002330472,0.0003846983,0.0006029746,0.0002413938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9346191,0.00246426,0.0008255365,0.00003912924,0.002587302,0.0000537254,0.001497967,0.0001441008,0.008479008,0.000008303209,0.00005858835,0.04922302],"study_design_scores_gemma":[0.9424807,0.05291258,0.001299418,0.0001965561,0.00008553876,0.00009318785,0.0009741356,0.00003765875,0.001307087,0.00000956017,0.000456871,0.0001466793],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903106,0.004181257,0.0001284216,0.002124628,0.0009075604,0.00224102,0.0000546398,0.000004712719,0.00004712922],"genre_scores_gemma":[0.9683706,0.02941231,0.00004578423,0.0003011,0.001497227,0.0003169807,0.000002395132,0.00003711568,0.00001651179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05044832,"threshold_uncertainty_score":0.6832265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1304309572939205,"score_gpt":0.4569970571346781,"score_spread":0.3265660998407576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}