{"id":"W3033719574","doi":"10.1200/jco.2020.38.18_suppl.lba2","title":"A randomized phase III trial of systemic therapy plus early local therapy versus systemic therapy alone in women with de novo stage IV breast cancer: A trial of the ECOG-ACRIN Research Group (E2108).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Randomized controlled trial; Systemic therapy; Clinical endpoint; Hazard ratio; Breast cancer; Cumulative incidence; Internal medicine; Proportional hazards model; Log-rank test; Cancer; Surgery; Oncology; Confidence interval; Cohort","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002835326,0.001842807,0.002445511,0.000503395,0.0004326946,0.0009739627,0.0008323555,0.00183208,0.007561323],"category_scores_gemma":[0.002019752,0.0005625868,0.001534724,0.0004110609,0.001079297,0.0009550619,0.0005486008,0.00314112,0.001017459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007193308,"about_ca_system_score_gemma":0.001369168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007106605,"about_ca_topic_score_gemma":0.001588064,"domain_scores_codex":[0.9990065,0.00067253,0.00003323765,0.0001294619,0.00004697804,0.0001114372],"domain_scores_gemma":[0.9988592,0.0004017114,0.000254439,0.00008643002,0.00004790448,0.0003503642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9792684,0.006690523,0.0004678745,0.0002918334,0.0003263894,0.00002480388,0.00003396048,0.0002428481,0.001145201,0.0001158976,0.0008058041,0.01058653],"study_design_scores_gemma":[0.9454134,0.05252784,0.0007409708,0.00002192376,0.0001621389,0.00002189395,0.00001303683,0.0002227495,0.000176144,0.0001460257,0.0005461542,0.000007631211],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744138,0.004726156,0.001081256,0.001624855,0.0009448318,0.01095784,0.002008907,0.0001779127,0.004064497],"genre_scores_gemma":[0.9601191,0.002799798,0.004013441,0.003520455,0.0007351508,0.01882133,0.002434435,0.00004979588,0.007506508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007561323,"threshold_uncertainty_score":0.02529514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1304309572939205,"score_gpt":0.4569970571346781,"score_spread":0.3265660998407576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}