{"id":"W3033756138","doi":"10.21037/tau.2020.03.33","title":"Genetics of hypogonadotropic hypogonadism","year":2021,"lang":"en","type":"review","venue":"Translational Andrology and Urology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Toronto General Hospital","funders":"","keywords":"Hypogonadotropic hypogonadism; Testosterone (patch); Kallmann syndrome; Human chorionic gonadotropin; Virilization; Fertility; Endocrinology; Medicine; Hypothalamic disease; Genetic testing; Biology; Internal medicine; Hormone; Androgen; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555967,0.0006268197,0.0003562071,0.0008080548,0.0004194319,0.000456183,0.000312401,0.0008783056,0.002362302],"category_scores_gemma":[0.0005250786,0.0001967131,0.0003439747,0.0006966219,0.0005025386,0.000211342,0.0004776166,0.0007053797,0.000331158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005059137,"about_ca_system_score_gemma":0.0006067866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003322693,"about_ca_topic_score_gemma":0.002896905,"domain_scores_codex":[0.999756,0.00005379665,0.00001520139,0.00005158754,0.00009608013,0.00002725367],"domain_scores_gemma":[0.9997639,0.00007230239,0.00006302701,0.000008043534,0.00002808701,0.00006456579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008198071,0.0003115848,0.294663,0.001229522,0.0007762954,0.2182238,0.003370866,0.003843852,0.2568585,0.03604579,0.02485459,0.1590024],"study_design_scores_gemma":[0.0003005403,0.0004874209,0.4179857,0.001083369,0.0005692909,0.4399618,0.001067988,0.003488166,0.00996068,0.01890218,0.1060091,0.0001836678],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9114887,0.04099008,0.008010228,0.008485537,0.0005203584,0.0001813932,0.001560211,0.000478109,0.02828535],"genre_scores_gemma":[0.9710358,0.01536268,0.00426565,0.00170854,0.0003351752,0.00005115281,0.0006713366,0.00006897504,0.006500627],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003322693,"threshold_uncertainty_score":0.007902741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0472325550747505,"score_gpt":0.3276658131816746,"score_spread":0.2804332581069242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}