{"id":"W3033756138","doi":"10.21037/tau.2020.03.33","title":"Genetics of hypogonadotropic hypogonadism","year":2021,"lang":"en","type":"review","venue":"Translational Andrology and Urology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Toronto General Hospital","funders":"","keywords":"Hypogonadotropic hypogonadism; Testosterone (patch); Kallmann syndrome; Human chorionic gonadotropin; Virilization; Fertility; Endocrinology; Medicine; Hypothalamic disease; Genetic testing; Biology; Internal medicine; Hormone; Androgen; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552738,0.0002937374,0.002091645,0.0002185549,0.00004259398,0.000002409496,0.00008044301,0.0006193073,0.0002323425],"category_scores_gemma":[0.00004939847,0.0002451064,0.0003459142,0.0001194641,0.0004425797,0.00001955293,0.00002848264,0.0004400478,0.00001320483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007763537,"about_ca_system_score_gemma":0.0004170916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003170468,"about_ca_topic_score_gemma":0.000005023488,"domain_scores_codex":[0.9983038,0.0002153868,0.0005844656,0.000528714,0.0001270083,0.0002406437],"domain_scores_gemma":[0.9989372,0.0003819873,0.0001901692,0.0002819235,0.0001191752,0.00008956834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007972884,0.0001090182,0.0005830355,0.002376058,0.0008369932,0.0001056417,0.00003812815,0.000002454427,0.00001642885,0.004884605,0.00005156155,0.9909164],"study_design_scores_gemma":[0.0008688327,0.0003974464,0.004081352,0.0001722484,0.002803873,0.003562812,0.000001328446,0.00001684309,0.00000111871,0.001129013,0.9867977,0.0001674514],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001006703,0.9963883,0.0002005991,0.001195205,0.0001562113,0.0004119897,0.00005366121,0.00001665229,0.0005707291],"genre_scores_gemma":[0.002512926,0.9959247,0.0005997289,0.0001680718,0.0002364711,0.00003128132,0.0002435311,0.00002934486,0.0002539265],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9907489,"threshold_uncertainty_score":0.9995148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0472325550747505,"score_gpt":0.3276658131816746,"score_spread":0.2804332581069242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}