{"id":"W3033778638","doi":"10.1177/1753425920929759","title":"Poor stimulation of bovine dendritic cells by <i>Mycobacterium bovis</i> culture supernatant and surface extract is associated with decreased activation of ERK and NF- <b>κ</b> B and higher expression of SOCS1 and 3","year":2020,"lang":"en","type":"article","venue":"Innate Immunity","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Genome British Columbia; Genome Prairie; Banting Research Foundation; Ministry of Agriculture - Saskatchewan; Genome Canada","keywords":"MAPK/ERK pathway; Mycobacterium bovis; Stimulation; Cell biology; Chemistry; Microbiology; Apoptosis; NF-κB; Biology; Molecular biology; Signal transduction; Medicine; Biochemistry; Mycobacterium tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210407,0.0001978056,0.0004312843,0.0000440458,0.0001215394,0.00001439665,0.00008385984,0.0002430614,0.00005059104],"category_scores_gemma":[0.0001217719,0.0001481888,0.00002716512,0.0001230918,0.0003952173,0.000250711,0.00008207217,0.0002561955,3.193307e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001183149,"about_ca_system_score_gemma":0.00003405413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004912028,"about_ca_topic_score_gemma":0.000003072782,"domain_scores_codex":[0.9988264,0.0003994558,0.0003607909,0.0001961332,0.00005958607,0.0001576089],"domain_scores_gemma":[0.9989514,0.000387298,0.0003367479,0.0001501655,0.0001462597,0.00002807433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003370038,0.0001503476,0.007373357,0.0001333916,0.0001573135,7.188451e-7,0.002108991,0.000001241999,0.9856551,0.000003615439,0.0001862289,0.0008596163],"study_design_scores_gemma":[0.002962272,0.0008583785,0.05743589,0.0002653425,0.00007110686,0.000007593122,0.0002986435,0.00001931968,0.9371284,0.00001123134,0.0007887944,0.0001529909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904016,0.008831275,0.00004344098,0.0001676867,0.00003552379,0.0002316681,0.0002542337,0.00001721282,0.00001735275],"genre_scores_gemma":[0.997734,0.001823556,0.00006761117,0.0001079267,0.000002821626,0.000002096915,0.0001414727,0.00001772679,0.0001027509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05006253,"threshold_uncertainty_score":0.6042964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092635654842149,"score_gpt":0.2233957749637887,"score_spread":0.2124694184153673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}