{"id":"W3033780168","doi":"10.1093/cid/ciaa718","title":"Continuous Prophylactic Antiretrovirals/Antiretroviral Therapy Since Birth Reduces Seeding and Persistence of the Viral Reservoir in Children Vertically Infected With Human Immunodeficiency Virus","year":2020,"lang":"en","type":"letter","venue":"Clinical Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; U.S. Army; EMD Serono; Université de Montréal; ViiV Healthcare; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense; Gilead Sciences; Styrelsen för Internationellt Utvecklingssamarbete; Henry M. Jackson Foundation; U.S. Department of Health and Human Services; National Institutes of Health; Generalitat de Catalunya","keywords":"Medicine; Persistence (discontinuity); Antiretroviral therapy; Virology; Human immunodeficiency virus (HIV); Seeding; Pediatrics; Viral load; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002602371,0.000130519,0.0001452213,0.0001601229,0.0001346301,0.0002549743,0.0001349679,0.000157938,0.0005064387],"category_scores_gemma":[0.001878123,0.0001044828,0.00009733607,0.0001258297,0.0001335514,0.0001737766,0.000146257,0.0002363814,0.00004723496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468726,"about_ca_system_score_gemma":0.0002655101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001758543,"about_ca_topic_score_gemma":0.002176845,"domain_scores_codex":[0.9998459,0.00004597621,0.00001106411,0.00002222255,0.00004280626,0.00003200347],"domain_scores_gemma":[0.9991183,0.0002010758,0.0003992971,0.00003565681,0.00008075903,0.0001649276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005824447,0.0001708715,0.9633505,0.00008424428,0.00004838148,0.0002723308,0.0004422265,0.0001361437,0.0123268,0.00003629665,0.0001390443,0.02241055],"study_design_scores_gemma":[0.00001823459,0.001741503,0.9936387,0.00002980077,0.00004641345,0.001002618,0.000187626,0.0003488933,0.002680185,0.00001330458,0.0002900371,0.000002599809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995115,0.0003521305,0.00002371314,0.000009384576,0.000001429059,0.000001261842,0.00001625504,0.00000241991,0.00008202349],"genre_scores_gemma":[0.9996336,0.0001685784,0.00008716388,0.000007283096,0.000002237257,0.000002180372,0.00004271798,7.29834e-7,0.00005553412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001758543,"threshold_uncertainty_score":0.003496587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696043290180352,"score_gpt":0.2922554610972248,"score_spread":0.2652950281954213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}