{"id":"W3033829306","doi":"10.1038/s41421-020-0167-x","title":"Inflammasome activation and regulation: toward a better understanding of complex mechanisms","year":2020,"lang":"en","type":"review","venue":"Cell Discovery","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1001,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Clalit Health Services; Canadian Institute for Advanced Research; Leona M. and Harry B. Helmsley Charitable Trust; Bill and Melinda Gates Foundation; Deutsche Forschungsgemeinschaft; Howard Hughes Medical Institute","keywords":"Inflammasome; AIM2; Caspase; Pyroptosis; Cell biology; Signal transducing adaptor protein; Caspase 1; Effector; Secretion; Multiprotein complex; Signal transduction; Biology; Programmed cell death; Neuroscience; Apoptosis; Inflammation; Immunology; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008714242,0.0009946579,0.001578653,0.002059961,0.000307751,0.001499185,0.001023146,0.00148094,0.002648592],"category_scores_gemma":[0.0006670165,0.0002657365,0.000422988,0.002115896,0.0009342377,0.002862749,0.001219052,0.002852645,0.0021107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009713072,"about_ca_system_score_gemma":0.001537553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006643593,"about_ca_topic_score_gemma":0.000781407,"domain_scores_codex":[0.9997224,0.00005020767,0.00003578905,0.00005307844,0.0001086391,0.00002985751],"domain_scores_gemma":[0.9996229,0.0001674633,0.00004086734,0.00001597578,0.0001070522,0.00004575131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001006295,0.00009530222,0.0001932836,0.02122358,0.00008132933,0.0003438743,0.0001595309,0.0005683567,0.006667437,0.0197465,0.03962543,0.9111947],"study_design_scores_gemma":[0.00001112155,0.0000731331,0.0004506148,0.00254309,0.00004158892,0.001122746,0.00007867406,0.0001100011,0.0008724972,0.006001297,0.9886723,0.00002288631],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008209096,0.9981077,0.0003214595,0.0004878892,0.0002682042,0.000003583299,0.00001187741,0.000009751197,0.0007075324],"genre_scores_gemma":[0.0004040918,0.9983568,0.0002754404,0.0002651761,0.0002924826,0.000005620259,0.00002202322,0.000001735861,0.0003766702],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002648592,"threshold_uncertainty_score":0.008860409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05195290428637296,"score_gpt":0.2693595755914847,"score_spread":0.2174066713051118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}