{"id":"W3033835980","doi":"10.1136/annrheumdis-2020-eular.638","title":"OP0053 SECUKINUMAB IMPROVES CLINICAL AND IMAGING OUTCOMES IN PATIENTS WITH PSORIATIC ARTHRITIS AND AXIAL MANIFESTATIONS WITH INADEQUATE RESPONSE TO NSAIDS: WEEK 52 RESULTS FROM THE MAXIMISE TRIAL","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of Toronto; University of Leeds; Perelman School of Medicine, University of Pennsylvania; Janssen Scientific Affairs; College of Medicine, Drexel University; University of Pennsylvania; Leids Universitair Medisch Centrum; Universiteit Leiden; Drexel University; Biogen; Celgene; Amgen; Pfizer; University of Washington; Bristol-Myers Squibb; Eli Lilly and Company","keywords":"Medicine; Secukinumab; Psoriatic arthritis; Clinical endpoint; BASDAI; Placebo; Axial spondyloarthritis; Mallinckrodt; Clinical trial; Internal medicine; Surgery; Arthritis; Sacroiliitis; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001659987,0.001135485,0.00223823,0.0002201726,0.0002505188,0.001250164,0.000538801,0.001022399,0.003467758],"category_scores_gemma":[0.001551646,0.000399841,0.002050868,0.0002679918,0.0006014623,0.0008162942,0.0004480701,0.002131708,0.0005669551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005860497,"about_ca_system_score_gemma":0.0003990105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007163703,"about_ca_topic_score_gemma":0.001961143,"domain_scores_codex":[0.99946,0.0002502333,0.00003637591,0.00007598256,0.00005718888,0.0001201655],"domain_scores_gemma":[0.9992193,0.0002416717,0.0002261826,0.00008628096,0.00004583951,0.0001806826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8990238,0.004159448,0.008528573,0.001383054,0.005589759,0.0001431728,0.0001212284,0.001166838,0.005607287,0.0002107561,0.003210936,0.07085519],"study_design_scores_gemma":[0.7333251,0.1453771,0.1065296,0.0003439524,0.006534496,0.0003382901,0.0001792996,0.001606332,0.001513873,0.0006616038,0.003478185,0.000112252],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888988,0.007649568,0.0001558149,0.0005591753,0.0001313875,0.0001440807,0.0004860358,0.00005599279,0.001919061],"genre_scores_gemma":[0.9951558,0.001712784,0.0002132646,0.0005435052,0.0001911998,0.0001426981,0.000579602,0.00001206639,0.001449083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003467758,"threshold_uncertainty_score":0.01160085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03580724281123344,"score_gpt":0.3007715974809737,"score_spread":0.2649643546697403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}