{"id":"W3033837114","doi":"10.1016/j.toxicon.2020.05.027","title":"Identification of cross-reactive human single-chain variable fragments against phospholipases A2 from Lachesis muta and Bothrops spp venoms","year":2020,"lang":"en","type":"article","venue":"Toxicon","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Bothrops; Biology; Antivenom; Venom; Hemolysis; Snake venom; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007173653,0.0001139282,0.0001632446,0.0000145982,0.0001039732,0.00003643275,0.0000867319,0.00008405292,0.00003599385],"category_scores_gemma":[0.0000971144,0.0001188896,0.000040485,0.00005017175,0.0001127009,0.000008445896,0.00008595172,0.00004617275,0.000009640119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001480453,"about_ca_system_score_gemma":0.00001482047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008680145,"about_ca_topic_score_gemma":0.00001015591,"domain_scores_codex":[0.9992537,0.00002925254,0.0002387625,0.0002808133,0.00008533517,0.0001121527],"domain_scores_gemma":[0.9995718,0.00001171595,0.0001576206,0.0001436626,0.0000554815,0.00005973332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005441287,0.0001051247,0.003162404,0.0000206776,0.00007811303,0.000001190206,0.0004870729,0.00003529221,0.9951994,0.0001056211,0.0001747959,0.0005758345],"study_design_scores_gemma":[0.0005823532,0.0003150751,0.01311179,0.00001504598,0.00003009965,6.231464e-7,0.0004592481,0.000183775,0.9817061,0.0001855751,0.00324679,0.0001635098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966223,0.0006482696,0.0005010072,0.0001049627,0.000040234,0.0001201506,0.0001340696,0.00001249116,0.001816462],"genre_scores_gemma":[0.9990348,0.00005028211,0.0001574175,0.0002837811,0.0001031818,0.00000936223,0.000141132,0.00001521262,0.0002048943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01349334,"threshold_uncertainty_score":0.4848177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02508566545291568,"score_gpt":0.2684020853847715,"score_spread":0.2433164199318558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}