{"id":"W3033917691","doi":"10.1161/circulationaha.120.046361","title":"Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk","year":2020,"lang":"en","type":"review","venue":"Circulation","topic":"Cardiovascular Health and Disease Prevention","field":"Medicine","cited_by":443,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton General Hospital; Population Health Research Institute","funders":"NIHR Newcastle Biomedical Research Centre; Wake Forest School of Medicine; Standortagentur Tirol; Bundesministerium für Bildung, Wissenschaft und Forschung; Syddansk Universitet; Medical Research Council; Leids Universitair Medisch Centrum; Bundesministerium für Verkehr, Innovation und Technologie; Novo Nordisk; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; Nierstichting; Deutsche Forschungsgemeinschaft; Novo Nordisk Fonden; Newcastle University; University of Oxford; University of Leicester; Peking University; National Institute for Health and Care Research; Österreichische Forschungsförderungsgesellschaft; Konyang University; Regeneron Pharmaceuticals; Mylan; European Commission; Sanofi; Kowa Company; Universiteit Leiden; British Heart Foundation; Universitetet i Oslo; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Göteborgs Universitet; Amgen; Austrian Science Fund; Universiteit Maastricht; Wirtschaftsagentur Wien; Gyeongsang National University; CARIM School for Cardiovascular Diseases, Universiteit Maastricht; Pfizer; Fresenius Medical Care North America; National Health and Medical Research Council; Ege Üniversitesi; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Intima-media thickness; Internal medicine; Surrogate endpoint; Relative risk; Randomized controlled trial; Cardiology; Stroke (engine); Myocardial infarction; Confidence interval; Surgery; Carotid arteries","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04490816,0.001631321,0.003817436,0.003842204,0.0002287225,0.001963462,0.001145796,0.001570895,0.001594693],"category_scores_gemma":[0.09002648,0.0006146749,0.006315151,0.003875373,0.001121881,0.0009868343,0.0008673043,0.00187366,0.0002366179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008163218,"about_ca_system_score_gemma":0.001857746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009071325,"about_ca_topic_score_gemma":0.001053294,"domain_scores_codex":[0.9619229,0.02988271,0.002939765,0.002138128,0.002836997,0.0002794853],"domain_scores_gemma":[0.8962038,0.07695588,0.02042717,0.00362717,0.002340918,0.0004450955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02602843,0.0005352776,0.3128324,0.101081,0.3332576,0.00028552,0.0003492185,0.02313993,0.002862803,0.005026069,0.004942331,0.1896594],"study_design_scores_gemma":[0.01394261,0.01465318,0.4259446,0.03938915,0.4045647,0.002105985,0.0002697112,0.03142632,0.009336874,0.02631138,0.03162845,0.0004269236],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1469681,0.7849962,0.0509165,0.004424775,0.0009709307,0.001361774,0.005708768,0.0002320631,0.004420874],"genre_scores_gemma":[0.875138,0.08737352,0.02970672,0.002013666,0.001093263,0.002119397,0.001997441,0.00006320103,0.000494957],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04490816,"threshold_uncertainty_score":0.2374998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03954852563830786,"score_gpt":0.3465487335837644,"score_spread":0.3070002079454565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}