{"id":"W3033917691","doi":"10.1161/circulationaha.120.046361","title":"Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk","year":2020,"lang":"en","type":"review","venue":"Circulation","topic":"Cardiovascular Health and Disease Prevention","field":"Medicine","cited_by":443,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton General Hospital; Population Health Research Institute","funders":"NIHR Newcastle Biomedical Research Centre; Wake Forest School of Medicine; Standortagentur Tirol; Bundesministerium für Bildung, Wissenschaft und Forschung; Syddansk Universitet; Medical Research Council; Leids Universitair Medisch Centrum; Bundesministerium für Verkehr, Innovation und Technologie; Novo Nordisk; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; Nierstichting; Deutsche Forschungsgemeinschaft; Novo Nordisk Fonden; Newcastle University; University of Oxford; University of Leicester; Peking University; National Institute for Health and Care Research; Österreichische Forschungsförderungsgesellschaft; Konyang University; Regeneron Pharmaceuticals; Mylan; European Commission; Sanofi; Kowa Company; Universiteit Leiden; British Heart Foundation; Universitetet i Oslo; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Göteborgs Universitet; Amgen; Austrian Science Fund; Universiteit Maastricht; Wirtschaftsagentur Wien; Gyeongsang National University; CARIM School for Cardiovascular Diseases, Universiteit Maastricht; Pfizer; Fresenius Medical Care North America; National Health and Medical Research Council; Ege Üniversitesi; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Intima-media thickness; Internal medicine; Surrogate endpoint; Relative risk; Randomized controlled trial; Cardiology; Stroke (engine); Myocardial infarction; Confidence interval; Surgery; Carotid arteries","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001368447,0.0005240091,0.002643976,0.0002537078,0.0002022855,0.00005312255,0.0001265681,0.0006355712,0.0000543805],"category_scores_gemma":[0.001421221,0.0004589746,0.007165463,0.0005171914,0.00005119595,0.0001212268,0.0000678596,0.0005482855,0.0002334646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003750375,"about_ca_system_score_gemma":0.001142249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003469906,"about_ca_topic_score_gemma":0.000001687542,"domain_scores_codex":[0.9962582,0.0006284485,0.0008587703,0.0009240168,0.0008968525,0.0004336986],"domain_scores_gemma":[0.9974688,0.0002084785,0.0004770186,0.0009559704,0.0003352407,0.0005544361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009943151,0.0000520243,0.0004924541,0.04415483,0.002345539,0.00003618475,0.00004874567,0.0000149409,3.721205e-7,0.00004116613,0.0001445753,0.9525697],"study_design_scores_gemma":[0.001944234,0.00002974738,0.005137093,0.01145416,0.02459691,0.0002535095,0.0000142939,0.0001708757,5.913515e-7,0.0002229639,0.9557343,0.0004413501],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009404144,0.9826559,0.008697415,0.00003685403,0.0008577059,0.007046205,0.0001410194,0.0002022608,0.0002686031],"genre_scores_gemma":[0.001609519,0.9900586,0.0008869314,0.00004650481,0.001545366,0.001303019,0.004383525,0.0001503003,0.00001625201],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9555897,"threshold_uncertainty_score":0.9997862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03954852563830786,"score_gpt":0.3465487335837644,"score_spread":0.3070002079454565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}