{"id":"W3033960814","doi":"10.1038/s41467-020-16586-x","title":"Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Medical Research Council; Wellcome; European Federation of Pharmaceutical Industries and Associations; Genome Canada; Novartis Pharma; Wellcome Trust; Pfizer","keywords":"Active site; Transferase; Heme; Biochemistry; Enzyme; Chemistry; Frameshift mutation; ATP synthase; Binding site; Biology; Stereochemistry; Biophysics; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534193,0.0002079558,0.0001928613,0.00005186339,0.0004647515,0.00006329799,0.0006132463,0.0002596712,0.00001132238],"category_scores_gemma":[0.0002564145,0.0002092734,0.00006695661,0.0002219935,0.0002183979,0.00001486454,0.0004054163,0.000653727,0.000004665035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008931397,"about_ca_system_score_gemma":0.00004678957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003729722,"about_ca_topic_score_gemma":0.00002729449,"domain_scores_codex":[0.998726,0.000176308,0.0002837627,0.0004525304,0.0001283515,0.0002330131],"domain_scores_gemma":[0.9982455,0.00002345445,0.0001686425,0.001292283,0.0001101628,0.0001599074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002414744,0.00004680307,0.00573441,0.00004026817,0.00003569208,0.000002433757,0.0001552328,0.00002750145,0.9842436,0.002367914,0.005721202,0.001600831],"study_design_scores_gemma":[0.00467143,0.000434422,0.2852412,0.0002676342,0.0003401129,0.0001076551,0.001523832,0.0008351391,0.5125278,0.001749531,0.1896546,0.002646569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647447,0.0314307,0.00002618434,0.002582231,0.00008407456,0.0002856812,0.0001410378,0.00005183895,0.0006534779],"genre_scores_gemma":[0.9942451,0.0008759117,0.003284397,0.0005656118,0.0002291213,0.00001351083,0.0006172186,0.00003316106,0.0001359769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4717157,"threshold_uncertainty_score":0.8533922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093942648457675,"score_gpt":0.2733246327063277,"score_spread":0.252385206221751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}