{"id":"W3034015560","doi":"10.1161/circulationaha.119.043061","title":"Phosphodiesterase 3A and Arterial Hypertension","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Genetics","funders":"Leibniz-Gemeinschaft; Sickkids Research Institute; Ruhr-Universität Bochum; Hospital for Sick Children; Deutsches Zentrum für Herz-Kreislaufforschung; Universität zu Lübeck; Berlin Institute of Health; University of Toronto; European Molecular Biology Laboratory; Auckland District Health Board","keywords":"Medicine; Phosphodiesterase; Cardiology; Internal medicine; Pharmacology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004457442,0.00007888458,0.00006941266,0.00001183806,0.00006916839,0.00002397219,0.00002439251,0.00007371691,0.00002144555],"category_scores_gemma":[0.00005104093,0.00007541083,0.00002778879,0.00004226998,0.00002888182,0.000006747769,0.00002724949,0.00002833256,0.000013357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004683613,"about_ca_system_score_gemma":0.00001225662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002743469,"about_ca_topic_score_gemma":0.000001517889,"domain_scores_codex":[0.9995115,0.00002709934,0.0001059664,0.000212646,0.00006432334,0.00007843468],"domain_scores_gemma":[0.9997502,0.000004465282,0.0000387676,0.00009088901,0.00003959729,0.00007608801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001390107,0.00001322274,0.00931924,0.00001149323,0.00001217829,0.000001694056,0.0001025665,0.0001662293,0.9815881,0.00006701872,0.001220229,0.007358982],"study_design_scores_gemma":[0.003083229,0.0002323396,0.6533105,0.00002369807,0.00005727018,0.00007737808,0.0001478713,0.01969558,0.238725,0.0002004015,0.08388399,0.0005628028],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916047,0.0002066756,0.006913975,0.0007156485,0.0002116332,0.0001049472,0.00000320539,0.00002270942,0.000216494],"genre_scores_gemma":[0.9978783,0.00003188568,0.0001629255,0.001399323,0.0003408038,0.000004470861,0.0001474816,0.00001009893,0.00002478717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7428631,"threshold_uncertainty_score":0.3075164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835572520933533,"score_gpt":0.2118928812003242,"score_spread":0.1935371559909889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}