{"id":"W3034015560","doi":"10.1161/circulationaha.119.043061","title":"Phosphodiesterase 3A and Arterial Hypertension","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Genetics","funders":"Leibniz-Gemeinschaft; Sickkids Research Institute; Ruhr-Universität Bochum; Hospital for Sick Children; Deutsches Zentrum für Herz-Kreislaufforschung; Universität zu Lübeck; Berlin Institute of Health; University of Toronto; European Molecular Biology Laboratory; Auckland District Health Board","keywords":"Medicine; Phosphodiesterase; Cardiology; Internal medicine; Pharmacology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984273,0.0003170291,0.0001556705,0.0002334482,0.0001532327,0.0002190557,0.0002257387,0.0005802177,0.001967196],"category_scores_gemma":[0.000128167,0.00006935597,0.0002562506,0.0001745582,0.0003175675,0.00010115,0.0002003616,0.0005795396,0.0002158502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420426,"about_ca_system_score_gemma":0.0002411169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008401762,"about_ca_topic_score_gemma":0.0008799705,"domain_scores_codex":[0.999947,0.00001459677,0.000004088084,0.00001211618,0.00001043101,0.00001175507],"domain_scores_gemma":[0.9998866,0.00002755628,0.0000434283,0.000005511409,0.000007829654,0.00002898541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01072813,0.001598655,0.09666305,0.002690473,0.0009944293,0.01530769,0.0002974361,0.002224439,0.603062,0.0227824,0.01527423,0.228377],"study_design_scores_gemma":[0.001596304,0.005734773,0.5866702,0.00107957,0.001729401,0.06964784,0.0003685753,0.006767217,0.1354196,0.03592754,0.1549267,0.0001322028],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7309276,0.2329835,0.006772173,0.01049294,0.0007847456,0.00009007296,0.001093913,0.0001891776,0.01666591],"genre_scores_gemma":[0.9450959,0.0455319,0.002900078,0.001106799,0.000447076,0.00005691571,0.0005085545,0.00001033716,0.004342472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001967196,"threshold_uncertainty_score":0.006580889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835572520933533,"score_gpt":0.2118928812003242,"score_spread":0.1935371559909889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}