{"id":"W3034016271","doi":"10.22215/etd/2015-11099","title":"Tissue Plasminogen Activator (tPA) Promotes Postnatal Cortical Neuron Survival in Vitro Via JAK2- and mTOR-Dependent Mechanisms","year":2015,"lang":"en","type":"dissertation","venue":"","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Neuroprotection; Tissue plasminogen activator; PI3K/AKT/mTOR pathway; Activator (genetics); Pharmacology; Medicine; Viability assay; Neuron; Plasminogen activator; Neuroscience; In vitro; Signal transduction; Chemistry; Cell biology; Biology; Internal medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157282,0.0002109056,0.0001807814,0.0002143032,0.0001287012,0.0002679995,0.0001124797,0.0000853583,0.001668825],"category_scores_gemma":[0.0000889369,0.00007253345,0.0002872734,0.0001636612,0.0001061268,0.0001844063,0.0001366123,0.000361068,0.0006730375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717313,"about_ca_system_score_gemma":0.0003248608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009295333,"about_ca_topic_score_gemma":0.001649753,"domain_scores_codex":[0.9999253,0.00001099579,0.000009027709,0.00001151839,0.00002128056,0.00002178507],"domain_scores_gemma":[0.9999574,0.00001083201,0.00000985208,0.00000459565,0.000009293301,0.000007980048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002056509,0.00005311955,0.0002233997,0.00009356199,0.000008731925,0.00008664391,0.00002161935,0.0000503786,0.9943177,0.0001374215,0.00009954523,0.004702152],"study_design_scores_gemma":[0.0000130258,0.0002810541,0.008137824,0.00001407461,0.00002335145,0.0002624429,0.00003416392,0.0003961507,0.9880977,0.00007448885,0.002662641,0.000003077889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758592,0.01035143,0.005211858,0.0001687694,0.00005733848,0.00005870639,0.001268987,0.0001079796,0.006915635],"genre_scores_gemma":[0.9778528,0.009969637,0.004249212,0.00005069473,0.0000199479,0.00007411528,0.0012492,0.00002098201,0.006513359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001668825,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030831594893429,"score_gpt":0.257398212368363,"score_spread":0.2470898964194287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}