{"id":"W3034018148","doi":"10.3389/fcvm.2020.00081","title":"LDL Receptor Pathway Regulation by miR-224 and miR-520d","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; American Heart Association","keywords":"LDL receptor; PCSK9; microRNA; Psychological repression; Biology; Three prime untranslated region; Cell biology; Receptor; Regulation of gene expression; RNA interference; Untranslated region; Gene expression; Messenger RNA; Lipoprotein; Gene; Cholesterol; Endocrinology; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544972,0.0003617992,0.0002632147,0.000231542,0.00017908,0.0004645309,0.0001447826,0.0002420474,0.0008368231],"category_scores_gemma":[0.0001573863,0.0002591827,0.0003993071,0.00008818368,0.0001930518,0.0001398957,0.0003041217,0.0003384458,0.0006576863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003288416,"about_ca_system_score_gemma":0.0001956697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003247336,"about_ca_topic_score_gemma":0.0002770443,"domain_scores_codex":[0.9997721,0.00004523069,0.00003060932,0.00005902199,0.00005329188,0.00003977091],"domain_scores_gemma":[0.9999017,0.00001452931,0.00003726335,0.00001557923,0.00001358531,0.00001735213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001947907,0.00001495005,0.00043068,0.00004642264,0.000008815219,0.00006464196,0.00001008952,0.00008647757,0.9971086,0.0001671853,0.00004591024,0.001821486],"study_design_scores_gemma":[0.0000407841,0.0001849909,0.007048737,0.00001046259,0.00004716524,0.0006369773,0.00003028,0.002149679,0.9832154,0.0001245284,0.006498755,0.00001222564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764132,0.007462279,0.00999803,0.0002408317,0.00009625227,0.00005577761,0.0006543915,0.000322803,0.004756311],"genre_scores_gemma":[0.9913551,0.001153924,0.004814178,0.0001093131,0.00001020267,0.000052266,0.0005646747,0.00003168567,0.001908613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008368231,"threshold_uncertainty_score":0.002799451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006854230554085057,"score_gpt":0.2003030035730058,"score_spread":0.1934487730189207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}