{"id":"W3034021106","doi":"10.1016/j.scr.2020.101856","title":"Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Libin Cardiovascular Institute of Alberta","funders":"Bundesministerium für Bildung und Forschung","keywords":"Induced pluripotent stem cell; Biology; Germ layer; Sendai virus; CRISPR; Ataxia; Reprogramming; Karyotype; Mutation; Dilated cardiomyopathy; Cardiomyopathy; Cell culture; Cell biology; Molecular biology; Cancer research; Genetics; Internal medicine; Embryonic stem cell; Cell; Chromosome; Heart failure; Gene; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002147693,0.0002397039,0.0002990664,0.0001215911,0.0001144818,0.0000839686,0.0001540841,0.0001568371,0.000006010768],"category_scores_gemma":[0.00004218147,0.0002248715,0.00004190637,0.0003565894,0.0001181584,0.000009650291,0.0002294345,0.0001954254,0.000003022145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001424785,"about_ca_system_score_gemma":0.00008659722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001505132,"about_ca_topic_score_gemma":0.00009185509,"domain_scores_codex":[0.9979941,0.0001498118,0.0003464449,0.0007014613,0.0004212579,0.0003868842],"domain_scores_gemma":[0.9988917,0.00004991274,0.0000681911,0.0002842757,0.0003630262,0.0003428678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002777301,0.0000418582,0.000288934,0.00008285981,0.00005999984,0.00001851122,0.001009654,0.004266559,0.9874282,0.000001405534,0.0004678814,0.006056346],"study_design_scores_gemma":[0.001569826,0.001909545,0.0003336408,0.00003257713,0.00004385935,0.000007211062,0.0003732392,0.02807834,0.9666822,0.000004845902,0.0006855557,0.0002791864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801336,0.003656109,0.01499945,0.0002637863,0.00002934594,0.0006719358,0.000162492,0.00002680821,0.00005647146],"genre_scores_gemma":[0.9968718,0.0004801912,0.001834532,0.000107179,0.0001792841,0.00005593261,0.0003605456,0.00005586469,0.00005464783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02381178,"threshold_uncertainty_score":0.9169993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0426946599574335,"score_gpt":0.3186197478782168,"score_spread":0.2759250879207834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}