{"id":"W3034021106","doi":"10.1016/j.scr.2020.101856","title":"Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Libin Cardiovascular Institute of Alberta","funders":"Bundesministerium für Bildung und Forschung","keywords":"Induced pluripotent stem cell; Biology; Germ layer; Sendai virus; CRISPR; Ataxia; Reprogramming; Karyotype; Mutation; Dilated cardiomyopathy; Cardiomyopathy; Cell culture; Cell biology; Molecular biology; Cancer research; Genetics; Internal medicine; Embryonic stem cell; Cell; Chromosome; Heart failure; Gene; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000348507,0.0004563465,0.0003497227,0.000544047,0.0004822125,0.000404688,0.0004011467,0.0008799805,0.004960924],"category_scores_gemma":[0.0003209607,0.0002060836,0.0004099266,0.0003334291,0.0002974779,0.0001898796,0.0004321882,0.001070814,0.001392682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002465234,"about_ca_system_score_gemma":0.000332905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006111221,"about_ca_topic_score_gemma":0.0009482296,"domain_scores_codex":[0.9997613,0.00002104377,0.00004720024,0.00006606417,0.0000735735,0.00003083588],"domain_scores_gemma":[0.9998271,0.00003212555,0.00002478505,0.00004160655,0.00002172063,0.0000527857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001687967,0.0002043837,0.002346854,0.00008636597,0.0000218428,0.003297894,0.0002412348,0.0002225094,0.9842924,0.0009490377,0.0007932858,0.007375366],"study_design_scores_gemma":[0.0001891113,0.0005793078,0.01613449,0.00005435374,0.00008228314,0.02505966,0.0002495855,0.002330289,0.9276621,0.0003082528,0.02730507,0.00004546716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634913,0.0006099669,0.01727704,0.0002770508,0.0001853745,0.0009376492,0.007517235,0.0004108502,0.009293539],"genre_scores_gemma":[0.9547161,0.000790449,0.02118867,0.0002676951,0.00002962766,0.001088235,0.01123581,0.0001930511,0.01049048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004960924,"threshold_uncertainty_score":0.01659596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0426946599574335,"score_gpt":0.3186197478782168,"score_spread":0.2759250879207834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}