{"id":"W3034026100","doi":"10.1097/qad.0000000000002603","title":"First-line HIV treatment outcomes following the introduction of integrase inhibitors in UK guidelines","year":2020,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; Centre for Global Health Research","funders":"Medical Research Council; University Hospitals Coventry and Warwickshire NHS Trust; Barts Health NHS Trust; Public Health England; North Bristol NHS Trust; King's College London; Imperial College London; Imperial College Healthcare NHS Trust; Middlesex University; St. George's, University of London; University Hospitals of Leicester NHS Trust; University College London; Chelsea and Westminster Hospital NHS Foundation Trust; King's College Hospital NHS Foundation Trust; University of Sussex; Wellcome Trust","keywords":"Hazard ratio; Discontinuation; Regimen; Internal medicine; Medicine; Interquartile range; Reverse-transcriptase inhibitor; Proportional hazards model; Confidence interval; Integrase inhibitor; Protease inhibitor (pharmacology); Cohort study; Viral load; Virology; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644203,0.0001716554,0.0003699063,0.0001094789,0.00004300313,0.000006827387,0.0000582658,0.00004467016,0.00004850328],"category_scores_gemma":[0.0004109659,0.00009245923,0.0001838959,0.0004246819,0.00002870562,0.00004146272,0.0000320284,0.00007462976,0.00008803353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150152,"about_ca_system_score_gemma":0.00005880585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001065997,"about_ca_topic_score_gemma":0.00007268484,"domain_scores_codex":[0.9989299,0.00002584158,0.0004575604,0.0002231623,0.000205188,0.0001583801],"domain_scores_gemma":[0.9995342,0.00008524262,0.00006623307,0.0002001843,0.00004214234,0.00007203424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007994932,0.0001989412,0.963524,0.00002235115,0.0004335014,0.00007008189,0.002582434,0.00008976761,0.0003152712,0.00009391631,0.01789,0.01469977],"study_design_scores_gemma":[0.0474481,0.006418224,0.3525145,0.001195402,0.004378478,0.00004478716,0.0181162,0.005591022,0.1474873,0.001075101,0.4139793,0.001751628],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8402732,0.0002286371,0.00009742086,0.1585272,0.0002511921,0.0004108805,0.000004308307,0.00006042538,0.000146698],"genre_scores_gemma":[0.9925611,0.0001111477,0.001866256,0.0003684287,0.0003497787,0.00005336057,0.0000731297,0.00002046295,0.004596338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6110095,"threshold_uncertainty_score":0.3770378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04004555716950611,"score_gpt":0.306370073427717,"score_spread":0.266324516258211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}