{"id":"W3034026100","doi":"10.1097/qad.0000000000002603","title":"First-line HIV treatment outcomes following the introduction of integrase inhibitors in UK guidelines","year":2020,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; Centre for Global Health Research","funders":"Medical Research Council; University Hospitals Coventry and Warwickshire NHS Trust; Barts Health NHS Trust; Public Health England; North Bristol NHS Trust; King's College London; Imperial College London; Imperial College Healthcare NHS Trust; Middlesex University; St. George's, University of London; University Hospitals of Leicester NHS Trust; University College London; Chelsea and Westminster Hospital NHS Foundation Trust; King's College Hospital NHS Foundation Trust; University of Sussex; Wellcome Trust","keywords":"Hazard ratio; Discontinuation; Regimen; Internal medicine; Medicine; Interquartile range; Reverse-transcriptase inhibitor; Proportional hazards model; Confidence interval; Integrase inhibitor; Protease inhibitor (pharmacology); Cohort study; Viral load; Virology; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001308938,0.0002533242,0.0006250917,0.0008468686,0.0005193227,0.001514895,0.0005880713,0.001197298,0.002753508],"category_scores_gemma":[0.01880213,0.0003851791,0.0006944871,0.001866465,0.0003399753,0.001238436,0.001317749,0.001485548,0.0003197787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001747757,"about_ca_system_score_gemma":0.001097532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06401788,"about_ca_topic_score_gemma":0.06166923,"domain_scores_codex":[0.9973071,0.0007052887,0.0003238675,0.0004426073,0.0006033223,0.0006178229],"domain_scores_gemma":[0.9854826,0.001227025,0.01037176,0.0003025788,0.001284682,0.001331457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000338067,0.00008251712,0.9945648,0.00004932099,0.00008382384,0.000144088,0.0002823266,0.00004154353,0.00004394823,0.00003338616,0.0006702727,0.003666062],"study_design_scores_gemma":[0.00004141826,0.0001230608,0.9989398,0.00008058082,0.00003460767,0.0001770584,0.0001929755,0.0001004019,0.00001790411,0.00002657877,0.0002562617,0.000009293075],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956517,0.001486755,0.00005861434,0.0004597968,0.00003215558,0.00003934283,0.001474164,0.000004830479,0.0007927479],"genre_scores_gemma":[0.9979293,0.0004024697,0.00006935842,0.0001738221,0.00002367508,0.00002567709,0.001090447,0.000002751382,0.0002824791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06401788,"threshold_uncertainty_score":0.1272905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04004555716950611,"score_gpt":0.306370073427717,"score_spread":0.266324516258211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}