{"id":"W3034100708","doi":"10.1161/strokeaha.119.027544","title":"Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities","year":2020,"lang":"en","type":"review","venue":"Stroke","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Biomedical Imaging and Bioengineering; Dementia Centre for Research Collaboration; Hjartavernd; Karl-Franzens-Universität Graz; National Institute on Aging; Centre for Cognitive Ageing and Cognitive Epidemiology; Ludwig-Maximilians-Universität München; Háskóli Íslands; Simon Fraser University; Murdoch University; Institut National de la Santé et de la Recherche Médicale; Neuroscience Research Australia; University of Oxford; Parkinson's UK; National Institute of Neurological Disorders and Stroke; McGovern Medical School; Agence Nationale de la Recherche; Biotechnology and Biological Sciences Research Council; National Center for PTSD, U.S. Department of Veterans Affairs; University of Sydney; Dr. John T. MacDonald Foundation; University of Southern California; Wellcome Trust; McKnight Foundation; University of Miami; Johns Hopkins University; University of Washington; Leonard M. Miller School of Medicine; University of California, San Diego; University of New South Wales; School of Medicine, Boston University; Medical Research Council; Leids Universitair Medisch Centrum; Universiteit Leiden; Medizinische Universität Graz; University of Texas Health Science Center at Houston","keywords":"Locus (genetics); Genome-wide association study; Dementia; Medicine; Genetic association; Genetics; Genetic architecture; Hyperintensity; Genetic epidemiology; Disease; Biology; Evolutionary biology; Bioinformatics; Quantitative trait locus; Gene; Single-nucleotide polymorphism; Pathology; Genotype; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002170751,0.0008971337,0.0007536002,0.001653712,0.000515815,0.0009863292,0.0009192431,0.001112786,0.003117985],"category_scores_gemma":[0.006009463,0.0003995676,0.002100339,0.00195698,0.001383847,0.0004783718,0.001189683,0.001110474,0.0002251154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003425459,"about_ca_system_score_gemma":0.0004356786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004287499,"about_ca_topic_score_gemma":0.004376999,"domain_scores_codex":[0.9976854,0.0004827982,0.0002350216,0.001175863,0.0002072686,0.0002135957],"domain_scores_gemma":[0.9954645,0.002095516,0.001326972,0.0006438529,0.0002089523,0.0002602006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001497707,0.00006076652,0.9681301,0.0002522924,0.007090877,0.0009500082,0.0002866087,0.0007676785,0.007832293,0.0007111841,0.0003847546,0.01203573],"study_design_scores_gemma":[0.0000883515,0.0001114679,0.9924349,0.00007672716,0.002384844,0.001004845,0.0001376858,0.0006904088,0.0009764807,0.001641349,0.0004343668,0.00001833833],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9919829,0.003980886,0.001969256,0.0003000134,0.00003874748,0.00001431364,0.0007842516,0.00004406605,0.0008854578],"genre_scores_gemma":[0.9982072,0.0005311774,0.0005877442,0.00005947977,0.00003598254,0.000008744057,0.0004299278,0.00001241717,0.0001273256],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004287499,"threshold_uncertainty_score":0.01148021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02720011054416959,"score_gpt":0.3323365172440584,"score_spread":0.3051364066998888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}