{"id":"W3034152397","doi":"10.1016/j.ejmech.2020.112411","title":"PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society; Ontario Research Foundation","keywords":"Chemistry; HDAC6; Druggability; Cancer research; Pharmacology; Histone deacetylase; Biochemistry; Biology; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002567316,0.0005282477,0.0008961837,0.0003599749,0.0002348081,0.0004576209,0.0005729585,0.0005774304,0.00306773],"category_scores_gemma":[0.0001317594,0.0001717694,0.0004053304,0.0005371604,0.0002682288,0.0003440221,0.0003727493,0.001676687,0.001334101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003599241,"about_ca_system_score_gemma":0.0005243409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005319768,"about_ca_topic_score_gemma":0.00137749,"domain_scores_codex":[0.9999079,0.00001336677,0.000009393813,0.00001747177,0.0000188019,0.00003301637],"domain_scores_gemma":[0.999962,0.000002658285,0.000005711491,0.000003871719,0.000005009321,0.00002079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00832338,0.00244942,0.0021285,0.00194955,0.0003486135,0.001716197,0.0001815938,0.003384592,0.4393699,0.004098587,0.02459029,0.5114594],"study_design_scores_gemma":[0.02656363,0.06221753,0.02722179,0.0004487959,0.001319684,0.01482389,0.0002083179,0.008292532,0.4387039,0.003438553,0.4164945,0.0002667755],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8662441,0.08952083,0.007209491,0.003565887,0.001611377,0.0008625328,0.002736037,0.00138455,0.02686518],"genre_scores_gemma":[0.9360675,0.04111204,0.005593651,0.001737871,0.0002537206,0.0003124384,0.003979642,0.00006855308,0.01087467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00306773,"threshold_uncertainty_score":0.01026261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02043275046612374,"score_gpt":0.2800599055009068,"score_spread":0.259627155034783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}