{"id":"W3034197414","doi":"10.1107/s205225252000696x","title":"Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism","year":2020,"lang":"en","type":"article","venue":"IUCrJ","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; Wellcome; Innovative Medicines Initiative; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institute of Diabetes and Digestive and Kidney Diseases; Boehringer Ingelheim; Merck; Takeda Pharmaceuticals U.S.A.; Pfizer","keywords":"Biochemistry; Oxidative decarboxylation; Catabolism; Chemistry; Dihydrolipoamide dehydrogenase; Lyase; Dehydrogenase; Decarboxylation; Lysine; Oxidoreductase; Active site; Protein structure; Tryptophan; Enzyme; Biology; Amino acid; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003246495,0.0001363383,0.0002429899,0.00004147001,0.00005119914,0.00001234852,0.0001157092,0.0000898707,0.00000732954],"category_scores_gemma":[0.0003766158,0.0001116304,0.00004015891,0.0001159034,0.0002361141,0.000007671259,0.0003752224,0.0001512531,4.947655e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001494156,"about_ca_system_score_gemma":0.00002408006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007634063,"about_ca_topic_score_gemma":0.0002377836,"domain_scores_codex":[0.9991235,0.00004978079,0.0002256868,0.000314402,0.0001308604,0.0001557731],"domain_scores_gemma":[0.9996153,0.00001383026,0.00006825302,0.0001280938,0.0001080922,0.00006649653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001991556,0.00002639203,0.0006842069,0.0001410232,0.00008834475,0.000002817738,0.001955634,0.000004044026,0.9951423,0.00002986576,0.001159623,0.0005665497],"study_design_scores_gemma":[0.0009346973,0.0003908056,0.002013826,0.00003316032,0.0000161351,0.000003451777,0.0006280231,0.00003069698,0.9855034,0.0003312422,0.00996411,0.0001503883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995631,0.002830642,0.00001632905,0.001135117,0.00006775783,0.0002038632,0.00002705084,0.000006925164,0.00008135704],"genre_scores_gemma":[0.9986748,0.0002217304,0.0004718383,0.0001471289,0.0003766704,0.00001488832,0.00006394852,0.00001088315,0.00001818893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009638879,"threshold_uncertainty_score":0.4552154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02806896735217457,"score_gpt":0.3310789066384535,"score_spread":0.303009939286279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}