{"id":"W3034197414","doi":"10.1107/s205225252000696x","title":"Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism","year":2020,"lang":"en","type":"article","venue":"IUCrJ","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; Wellcome; Innovative Medicines Initiative; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institute of Diabetes and Digestive and Kidney Diseases; Boehringer Ingelheim; Merck; Takeda Pharmaceuticals U.S.A.; Pfizer","keywords":"Biochemistry; Oxidative decarboxylation; Catabolism; Chemistry; Dihydrolipoamide dehydrogenase; Lyase; Dehydrogenase; Decarboxylation; Lysine; Oxidoreductase; Active site; Protein structure; Tryptophan; Enzyme; Biology; Amino acid; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162352,0.0004985943,0.000458406,0.0002374425,0.0003615301,0.0005764071,0.000502575,0.0005297397,0.002289407],"category_scores_gemma":[0.000264563,0.0002791324,0.0003405478,0.0003323805,0.0001492034,0.0003040693,0.0003321375,0.0009846846,0.0004875565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008687629,"about_ca_system_score_gemma":0.0003536368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003242944,"about_ca_topic_score_gemma":0.004226409,"domain_scores_codex":[0.9999038,0.00001263357,0.000006503342,0.00002377191,0.00003478813,0.00001842683],"domain_scores_gemma":[0.9999019,0.00002184851,0.00001683451,0.000006377483,0.00001847423,0.00003464847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001204733,0.0004022982,0.01570102,0.001048825,0.0003339689,0.002778279,0.0006626925,0.009935189,0.9285882,0.002122197,0.01078058,0.02644203],"study_design_scores_gemma":[0.0006613687,0.0007893532,0.1324626,0.0001511095,0.000567946,0.006955714,0.001587451,0.1206604,0.6093823,0.00183065,0.1247414,0.0002098087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785886,0.01053324,0.003514026,0.0008596242,0.0001139393,0.00003031615,0.00243484,0.0002126495,0.003712746],"genre_scores_gemma":[0.9717708,0.005353893,0.009550939,0.0001803919,0.00002482096,0.00002044511,0.00952774,0.00005501274,0.003516009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003242944,"threshold_uncertainty_score":0.007658839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02806896735217457,"score_gpt":0.3310789066384535,"score_spread":0.303009939286279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}