{"id":"W3034205717","doi":"10.1038/s41598-020-65665-y","title":"Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; Centre hospitalier universitaire de Québec; McGill University; University Health Network; University of Toronto; Royal Victoria Hospital; Queen's University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Fogarty International Center; National Heart, Lung, and Blood Institute; Biomedical Research Council; Instituto de Salud Carlos III; Cancer Council Western Australia; Cancer Council Victoria; World Cancer Research Fund; Medical Research Council; Manchester Biomedical Research Centre; Center for Agroforestry, University of Missouri; University of California, Irvine; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Ministry of Science and Higher Education of the Russian Federation; Mutuelle Générale de l'Education Nationale; Imperial Experimental Cancer Medicine Centre; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Ministry of Education, Science and Technology; Academia Sinica; Deutsche Krebshilfe; Cancer Institute NSW; Medizinischen Hochschule Hannover; Memorial Sloan-Kettering Cancer Center; Centre International de Recherche sur le Cancer; Kreftforeningen; Institut National Du Cancer; Oak Foundation; Leids Universitair Medisch Centrum; Instituto Mexicano del Seguro Social; KWF Kankerbestrijding; Vetenskapsrådet; National Medical Research Council; Norges Forskningsråd; Stockholms Läns Landsting; University of Westminster; Ligue Contre le Cancer; California Department of Public Health; National Research Foundation of Korea; Alexander von Humboldt-Stiftung; University of Southern California; Cancerfonden; Itä-Suomen Yliopisto; Eberhard Karls Universität Tübingen; American Cancer Society; Russian Foundation for Basic Research; Kuopion Yliopistollinen Sairaala; Cancer Research Institute; University of Crete; Institut National de la Santé et de la Recherche Médicale; Wellcome Trust; Agence Nationale de la Recherche; Japan Agency for Medical Research and Development; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; National Breast Cancer Foundation; Rosetrees Trust; Canadian Institutes of Health Research; European Commission; Stavros Niarchos Foundation; Fondation de France; University of Utah; National Research Foundation; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; National Cancer Institute; European Regional Development Fund; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Government of Canada; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Swedish Cancer Foundation; Pancreatic Cancer UK; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Korea Health Industry Development Institute; McGill University Health Centre; Institute of Biomedical Sciences, Academia Sinica; David F. and Margaret T. Grohne Family Foundation; Consejo Nacional de Ciencia y Tecnología; Sundhed og Sygdom, Det Frie Forskningsråd; Deutsches Krebsforschungszentrum; National Research Foundation Singapore; Centers for Disease Control and Prevention; National Institute for Health and Care Research; National Institutes of Health; Division of Cancer Prevention, National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Karolinska Institutet; Huntsman Cancer Foundation; Harvard T.H. Chan School of Public Health; University College London; Cancer Research UK; Fondation du cancer du sein du Québec; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Avon Foundation for Women; Ministry of Public Health; Ministry of Education, Culture, Sports, Science and Technology; Beckman Research Institute, City of Hope; Royal Marsden NHS Foundation Trust; Université Laval; Genome Canada; Brigham and Women's Hospital; Robert Bosch Stiftung; National Cancer Research Institute; U.S. Department of Health and Human Services; Fonds Wetenschappelijk Onderzoek; Huntsman Cancer Institute; Servicio Gallego de Salud; China Scholarship Council; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; McGill University; Breast Cancer Research Foundation; Universitätsklinikum Hamburg-Eppendorf; Xunta de Galicia; Dr. Ralph and Marian Falk Medical Research Trust; Taiwan Biobank; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado","keywords":"Germline; Breast cancer; Germline mutation; Genetics; Biology; Cancer; Medicine; Mutation; Oncology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005906509,0.0002000497,0.0003200844,0.0001475672,0.0003176257,0.0002076087,0.00007040166,0.0001125001,0.0008531356],"category_scores_gemma":[0.0002818926,0.0001826377,0.00009903201,0.0005879471,0.0003714715,0.0001721002,0.00006682261,0.0002937496,0.00003192628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008094379,"about_ca_system_score_gemma":0.0006727955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007778185,"about_ca_topic_score_gemma":0.0001229361,"domain_scores_codex":[0.9975092,0.00006740349,0.000506344,0.001002594,0.0005994519,0.0003149541],"domain_scores_gemma":[0.9978721,0.0000215429,0.000313637,0.0007281079,0.0003888651,0.0006757851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006019659,0.0004989389,0.08557506,0.0002588012,0.0003813258,0.004964034,0.004256716,0.0006198821,0.8338934,0.0001801675,0.04173752,0.02703222],"study_design_scores_gemma":[0.009016302,0.0007489105,0.5335212,0.0008126007,0.002464291,0.01416252,0.00117968,0.01990903,0.1619559,0.001790729,0.2523507,0.002088176],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992574,0.0005981051,0.0003520621,0.002646724,0.001733924,0.0006450355,0.0002215285,0.000168978,0.001059682],"genre_scores_gemma":[0.9977478,0.00004408696,0.0004995949,0.0005719289,0.0002450243,0.00004164894,0.0003300547,0.00004035678,0.0004794598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6719375,"threshold_uncertainty_score":0.9341236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694305519063219,"score_gpt":0.2710328341484896,"score_spread":0.2540897789578573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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