{"id":"W3034205717","doi":"10.1038/s41598-020-65665-y","title":"Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; Centre hospitalier universitaire de Québec; McGill University; University Health Network; University of Toronto; Royal Victoria Hospital; Queen's University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Fogarty International Center; National Heart, Lung, and Blood Institute; Biomedical Research Council; Instituto de Salud Carlos III; Cancer Council Western Australia; Cancer Council Victoria; World Cancer Research Fund; Medical Research Council; Manchester Biomedical Research Centre; Center for Agroforestry, University of Missouri; University of California, Irvine; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Ministry of Science and Higher Education of the Russian Federation; Mutuelle Générale de l'Education Nationale; Imperial Experimental Cancer Medicine Centre; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Ministry of Education, Science and Technology; Academia Sinica; Deutsche Krebshilfe; Cancer Institute NSW; Medizinischen Hochschule Hannover; Memorial Sloan-Kettering Cancer Center; Centre International de Recherche sur le Cancer; Kreftforeningen; Institut National Du Cancer; Oak Foundation; Leids Universitair Medisch Centrum; Instituto Mexicano del Seguro Social; KWF Kankerbestrijding; Vetenskapsrådet; National Medical Research Council; Norges Forskningsråd; Stockholms Läns Landsting; University of Westminster; Ligue Contre le Cancer; California Department of Public Health; National Research Foundation of Korea; Alexander von Humboldt-Stiftung; University of Southern California; Cancerfonden; Itä-Suomen Yliopisto; Eberhard Karls Universität Tübingen; American Cancer Society; Russian Foundation for Basic Research; Kuopion Yliopistollinen Sairaala; Cancer Research Institute; University of Crete; Institut National de la Santé et de la Recherche Médicale; Wellcome Trust; Agence Nationale de la Recherche; Japan Agency for Medical Research and Development; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; National Breast Cancer Foundation; Rosetrees Trust; Canadian Institutes of Health Research; European Commission; Stavros Niarchos Foundation; Fondation de France; University of Utah; National Research Foundation; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; National Cancer Institute; European Regional Development Fund; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Government of Canada; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Swedish Cancer Foundation; Pancreatic Cancer UK; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Korea Health Industry Development Institute; McGill University Health Centre; Institute of Biomedical Sciences, Academia Sinica; David F. and Margaret T. Grohne Family Foundation; Consejo Nacional de Ciencia y Tecnología; Sundhed og Sygdom, Det Frie Forskningsråd; Deutsches Krebsforschungszentrum; National Research Foundation Singapore; Centers for Disease Control and Prevention; National Institute for Health and Care Research; National Institutes of Health; Division of Cancer Prevention, National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Karolinska Institutet; Huntsman Cancer Foundation; Harvard T.H. Chan School of Public Health; University College London; Cancer Research UK; Fondation du cancer du sein du Québec; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Avon Foundation for Women; Ministry of Public Health; Ministry of Education, Culture, Sports, Science and Technology; Beckman Research Institute, City of Hope; Royal Marsden NHS Foundation Trust; Université Laval; Genome Canada; Brigham and Women's Hospital; Robert Bosch Stiftung; National Cancer Research Institute; U.S. Department of Health and Human Services; Fonds Wetenschappelijk Onderzoek; Huntsman Cancer Institute; Servicio Gallego de Salud; China Scholarship Council; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; McGill University; Breast Cancer Research Foundation; Universitätsklinikum Hamburg-Eppendorf; Xunta de Galicia; Dr. Ralph and Marian Falk Medical Research Trust; Taiwan Biobank; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado","keywords":"Germline; Breast cancer; Germline mutation; Genetics; Biology; Cancer; Medicine; Mutation; Oncology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002621263,0.000433709,0.001069658,0.001301305,0.0005872927,0.000856413,0.0003895001,0.0006356121,0.00252241],"category_scores_gemma":[0.006591158,0.0002555531,0.001218069,0.0014222,0.0005895759,0.0002875493,0.000744401,0.0003619368,0.0002355525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002286015,"about_ca_system_score_gemma":0.0002550521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002970417,"about_ca_topic_score_gemma":0.003432358,"domain_scores_codex":[0.9964883,0.001307057,0.0004779796,0.0008919672,0.0005763979,0.0002582341],"domain_scores_gemma":[0.9951707,0.00227023,0.001326094,0.0007616609,0.0002973593,0.0001739885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001292145,0.00002804091,0.9817669,0.0001306616,0.002393027,0.001164239,0.000146433,0.000195584,0.006252162,0.00009769827,0.000113485,0.006419573],"study_design_scores_gemma":[0.00007710919,0.0002702053,0.9919911,0.00003638738,0.001813252,0.002794797,0.0001030573,0.0001804082,0.001322528,0.0001621816,0.001239175,0.000009919128],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956078,0.002569618,0.0004740682,0.00003894396,0.00001273016,0.00002154701,0.0002847328,0.00001068234,0.0009799894],"genre_scores_gemma":[0.9992158,0.0002955258,0.000118167,0.00002339475,0.00001195278,0.000007740284,0.0001991249,0.000004716178,0.0001234841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002970417,"threshold_uncertainty_score":0.01386273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694305519063219,"score_gpt":0.2710328341484896,"score_spread":0.2540897789578573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}