{"id":"W3034335761","doi":"10.3390/cells9061430","title":"High Throughput strategies Aimed at Closing the GAP in Our Knowledge of Rho GTPase Signaling","year":2020,"lang":"en","type":"review","venue":"Cells","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"GTPase; Biology; Cell biology; Effector; Cytoskeleton; Computational biology; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001037079,0.001013149,0.001688843,0.002557378,0.0003507193,0.001494216,0.001345688,0.00117929,0.003447021],"category_scores_gemma":[0.0007485225,0.0004457879,0.0007738213,0.001811333,0.0007886649,0.00220896,0.001177163,0.003273964,0.003801801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001120416,"about_ca_system_score_gemma":0.001048097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006364684,"about_ca_topic_score_gemma":0.0008702716,"domain_scores_codex":[0.9995921,0.00007584967,0.00003324008,0.00006546488,0.0001858114,0.00004751597],"domain_scores_gemma":[0.9996969,0.0001216624,0.00003082566,0.0000204394,0.00009347515,0.00003680176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001460304,0.0001488416,0.0001779527,0.01915682,0.0001888466,0.0004527032,0.0001180154,0.001030296,0.02083262,0.03075352,0.05473381,0.8722606],"study_design_scores_gemma":[0.00001418268,0.00007636532,0.0003048807,0.0007229128,0.00007420586,0.000595761,0.00002713317,0.0001867919,0.00307008,0.003425224,0.9914789,0.00002344034],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002602639,0.9957057,0.001150439,0.0004767771,0.0003183066,0.00001093662,0.00003382062,0.00003947911,0.002004419],"genre_scores_gemma":[0.001720671,0.9955363,0.0008678688,0.0003404758,0.000237882,0.00001955125,0.00008159807,0.000006781715,0.001188786],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003447021,"threshold_uncertainty_score":0.01153147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03845954993751671,"score_gpt":0.3192831096888766,"score_spread":0.2808235597513599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}