{"id":"W3034357715","doi":"10.1080/14740338.2020.1776699","title":"Safety and tolerability of IV ketamine in adults with major depressive or bipolar disorder: results from the Canadian rapid treatment center of excellence","year":2020,"lang":"en","type":"article","venue":"Expert Opinion on Drug Safety","topic":"Treatment of Major Depression","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Brain and Cognition Discovery Foundation; University Health Network","funders":"","keywords":"Tolerability; Ketamine; Medicine; Adverse effect; Nausea; Anesthesia; Blood pressure; Dissociative; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004502347,0.0002326201,0.0006016137,0.0003327349,0.0003789156,0.0007442225,0.0007096285,0.0003854504,0.001235806],"category_scores_gemma":[0.01404487,0.0001061345,0.0004894506,0.0009451088,0.000370752,0.0001945429,0.0002662508,0.0004060247,0.0002141163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006240393,"about_ca_system_score_gemma":0.01414566,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.4494527,"about_ca_topic_score_gemma":0.6471099,"domain_scores_codex":[0.9960443,0.0006423292,0.000371875,0.0002550712,0.00236524,0.0003211696],"domain_scores_gemma":[0.9862453,0.001684395,0.003757055,0.0001833056,0.007298705,0.0008312782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01221162,0.0005044474,0.3323424,0.005289024,0.001401271,0.0002144836,0.0007053596,0.0009174241,0.002103605,0.0003241617,0.05468998,0.5892964],"study_design_scores_gemma":[0.001642597,0.002473697,0.9751701,0.001803708,0.0007782418,0.0001806065,0.0003120445,0.000360705,0.000507893,0.00005959787,0.01667027,0.00004053568],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.772024,0.1718445,0.0008669199,0.009711922,0.0003867146,0.001232913,0.01899039,0.00009791141,0.0248446],"genre_scores_gemma":[0.9132684,0.06871708,0.00183268,0.003559596,0.0002528007,0.000257923,0.01076899,0.00003422813,0.001308165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5505474,"threshold_uncertainty_score":0.8936731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756774449392825,"score_gpt":0.2581846634628854,"score_spread":0.2406169189689572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}