{"id":"W3034412186","doi":"10.1002/pro.3898","title":"The long form of <scp>pVHL</scp> is artifactually modified by serine protease inhibitor <scp>AEBSF</scp>","year":2020,"lang":"en","type":"article","venue":"Protein Science","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Serine protease; Gene isoform; Chemistry; Protease; Serine; Protease inhibitor (pharmacology); Biochemistry; Alternative splicing; Molecular biology; Cell biology; Biology; Enzyme; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006515617,0.0002534399,0.0002491623,0.0000420078,0.0003490201,0.0001332965,0.0009041057,0.0001233217,0.000005205416],"category_scores_gemma":[0.001603347,0.0001933964,0.0001287643,0.0005296873,0.0007436877,0.00003833569,0.0004318262,0.0001883198,0.00002019794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002047287,"about_ca_system_score_gemma":0.0004810165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005247154,"about_ca_topic_score_gemma":0.00002113593,"domain_scores_codex":[0.9975675,0.00004549642,0.0004007079,0.0007082187,0.0006320602,0.0006460351],"domain_scores_gemma":[0.9984769,0.0000361637,0.0002620066,0.0005856589,0.0002718386,0.0003674896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001591059,0.00004451106,0.000118488,0.00004837757,0.00001440345,9.127464e-7,0.0005689519,0.00001299086,0.9854581,0.0000904526,0.005386228,0.008240642],"study_design_scores_gemma":[0.0003985701,0.0002422326,0.000356717,0.00001708088,0.00001103809,0.000004420158,0.0001757001,0.0002483182,0.841944,0.0001956144,0.1563499,0.00005639291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918957,0.002784325,0.001903848,0.0005175339,0.0002956285,0.001338584,0.00006658203,0.00002892098,0.001168839],"genre_scores_gemma":[0.9947292,0.0003795811,0.0005661055,0.0007686637,0.0007011545,0.0002628201,0.00001423122,0.00002809396,0.002550142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1509637,"threshold_uncertainty_score":0.7886477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309838532700811,"score_gpt":0.2409879624613946,"score_spread":0.2278895771343865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}