{"id":"W3034426829","doi":"10.1038/s41467-020-16786-5","title":"A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; University of Washington; Jacobs Foundation; Helsingin Yliopisto; York University; National Cancer Institute; School of Medicine, New York University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Tropomyosin receptor kinase B; Biology; Receptor tyrosine kinase; Alternative splicing; Cancer research; Trk receptor; Protein kinase B; Carcinogenesis; Tyrosine kinase; Signal transduction; RNA splicing; Cell biology; Genetics; Computational biology; Gene; Neurotrophin; Neurotrophic factors; Exon; Receptor; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099162,0.0003134966,0.0002307336,0.0003900757,0.000143589,0.0002362092,0.0001318217,0.0002915404,0.001523613],"category_scores_gemma":[0.0002008967,0.0001015294,0.0001562592,0.0002473864,0.0002968189,0.0001303355,0.000129087,0.0002434015,0.0005235071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000158555,"about_ca_system_score_gemma":0.0001738966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004379211,"about_ca_topic_score_gemma":0.0006933259,"domain_scores_codex":[0.9998865,0.00001265957,0.00001340891,0.00002902557,0.0000366919,0.00002177999],"domain_scores_gemma":[0.9998534,0.00001503683,0.00005558163,0.00001556519,0.00001401425,0.00004639327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005148808,0.00003779646,0.008456957,0.00003728543,0.00002128597,0.00340427,0.00003895284,0.00007915639,0.983561,0.0003006618,0.0001856235,0.003362085],"study_design_scores_gemma":[0.0001131171,0.001084989,0.2348634,0.00002527447,0.0001813551,0.1696494,0.0003439773,0.001951525,0.5813304,0.001499103,0.008915853,0.00004156288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973692,0.0005343462,0.0006470046,0.00006846774,0.00001223439,0.000006157866,0.0001449658,0.00004392533,0.001173751],"genre_scores_gemma":[0.9986629,0.0002333798,0.0003159716,0.0000275882,0.000009685054,0.000004412526,0.0002243869,0.00001646575,0.0005052164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001523613,"threshold_uncertainty_score":0.005096972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384815070580142,"score_gpt":0.2851769435435342,"score_spread":0.2613287928377327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}