{"id":"W3034426829","doi":"10.1038/s41467-020-16786-5","title":"A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; University of Washington; Jacobs Foundation; Helsingin Yliopisto; York University; National Cancer Institute; School of Medicine, New York University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Tropomyosin receptor kinase B; Biology; Receptor tyrosine kinase; Alternative splicing; Cancer research; Trk receptor; Protein kinase B; Carcinogenesis; Tyrosine kinase; Signal transduction; RNA splicing; Cell biology; Genetics; Computational biology; Gene; Neurotrophin; Neurotrophic factors; Exon; Receptor; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002050032,0.0001095318,0.0001196356,0.00005079102,0.0001656133,0.00003788857,0.0005392226,0.0001929182,0.000004267972],"category_scores_gemma":[0.0003315101,0.0001051119,0.0000465433,0.000223635,0.00009536315,0.000006463747,0.0005476308,0.0004652476,0.000003937935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000170481,"about_ca_system_score_gemma":0.0000762963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004303612,"about_ca_topic_score_gemma":0.0001493637,"domain_scores_codex":[0.9991323,0.0001278769,0.0001697727,0.0002476563,0.0001110729,0.0002112888],"domain_scores_gemma":[0.9990612,0.00007757475,0.00004642861,0.0006224518,0.00007972705,0.0001126497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005914381,0.00006034534,0.0008212885,0.00001542743,0.00002153185,0.000008516591,0.0003336206,0.00008350147,0.9962957,0.001295219,0.0004404407,0.0005652658],"study_design_scores_gemma":[0.006025489,0.00150646,0.01894395,0.0002702771,0.0001134734,0.0002723577,0.004826817,0.07130112,0.7976317,0.0009756751,0.09641806,0.001714658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808065,0.01510803,0.0003237664,0.003091041,0.00001857363,0.0002250279,0.00003402665,0.00001717484,0.0003758551],"genre_scores_gemma":[0.9953502,0.0008857953,0.002977164,0.0005512557,0.00004608443,0.0000366663,0.0001081645,0.00001435649,0.00003034331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.198664,"threshold_uncertainty_score":0.428634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384815070580142,"score_gpt":0.2851769435435342,"score_spread":0.2613287928377327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}