{"id":"W3034508650","doi":"10.1007/s43032-020-00223-5","title":"Oleic Acid Counters Impaired Blastocyst Development Induced by Palmitic Acid During Mouse Preimplantation Development: Understanding Obesity-Related Declines in Fertility","year":2020,"lang":"en","type":"article","venue":"Reproductive Sciences","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Blastocyst; XBP1; Unfolded protein response; Palmitic acid; Andrology; Internal medicine; Oleic acid; Reproductive technology; Endocrinology; Biology; Inner cell mass; Reactive oxygen species; Tauroursodeoxycholic acid; Fatty acid; Endoplasmic reticulum; Chemistry; Embryo; Embryogenesis; Cell biology; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000311712,0.0004350996,0.0003891829,0.000486869,0.0002075256,0.0002970429,0.000328145,0.000512604,0.0008734172],"category_scores_gemma":[0.0001456134,0.0002286187,0.0004035077,0.0002243535,0.0002549814,0.0004465707,0.0002723272,0.0009614716,0.0002480704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490235,"about_ca_system_score_gemma":0.0002900787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005295055,"about_ca_topic_score_gemma":0.001228996,"domain_scores_codex":[0.9998209,0.00003146786,0.00002448391,0.00003995746,0.00004285854,0.00004036487],"domain_scores_gemma":[0.9998797,0.00001535176,0.00003801824,0.00001263192,0.00001837975,0.00003590943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001791172,0.00003210988,0.000253531,0.00004771203,0.000005324482,0.00004211801,0.00001604989,0.00002308772,0.9982497,0.00004628773,0.00001944474,0.001085452],"study_design_scores_gemma":[0.00001902606,0.0005265686,0.007350887,0.00001419617,0.00003275383,0.0001390295,0.0000442923,0.0003992627,0.9893027,0.00006952956,0.002096429,0.000005435738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779547,0.01139837,0.007103425,0.0004003305,0.0001048746,0.00009778631,0.0008240407,0.0001646985,0.001951777],"genre_scores_gemma":[0.9805063,0.007783622,0.005620666,0.0002481259,0.00003173737,0.0001638442,0.0009382186,0.00004461853,0.004662815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008734172,"threshold_uncertainty_score":0.002921879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07850175511668378,"score_gpt":0.296031058513126,"score_spread":0.2175293033964422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}