{"id":"W3034521924","doi":"10.1186/s12883-020-01811-3","title":"Study protocol of the DUtch PARkinson Cohort (DUPARC): a prospective, observational study of de novo Parkinson’s disease patients for the identification and validation of biomarkers for Parkinson’s disease subtypes, progression and pathophysiology","year":2020,"lang":"en","type":"article","venue":"BMC Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitair Medisch Centrum Groningen; European Commission; Weston Brain Institute; H2020 Marie Skłodowska-Curie Actions; Glaucoma Research Foundation","keywords":"Medicine; Parkinson's disease; Cohort; Neurology; Prospective cohort study; Cohort study; Internal medicine; Disease; Neuropsychology; Oncology; Cognition; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003493589,0.0002212945,0.000416996,0.00006679348,0.0001646291,0.00001034858,0.0001572747,0.00006287211,0.000003246455],"category_scores_gemma":[0.0006568204,0.0001417754,0.0001126346,0.0002041296,0.000163684,0.00007066393,0.0001198576,0.00007780985,1.454329e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002495745,"about_ca_system_score_gemma":0.0002267958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001769942,"about_ca_topic_score_gemma":0.00001860265,"domain_scores_codex":[0.9978642,0.0003637272,0.0006124087,0.0006157429,0.0003319535,0.000211924],"domain_scores_gemma":[0.9980881,0.0003365874,0.0006665686,0.0003923401,0.0003337701,0.0001827012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02383513,0.004344506,0.9684122,0.0005485496,0.0002320235,0.000003618993,0.0004378655,0.00002638176,0.001197302,0.00004768778,0.00004334845,0.0008714497],"study_design_scores_gemma":[0.01033706,0.004405503,0.9803432,0.00002817892,0.0009428097,9.65239e-7,0.0001007067,0.001700282,0.000917498,0.0005799367,0.0005463331,0.0000975819],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8838451,0.00004692811,0.0002058828,0.0003804441,0.00006616519,0.1152086,0.0002310609,0.00001476708,0.000001096406],"genre_scores_gemma":[0.9115146,0.000008337851,0.0001828457,0.0001261639,0.00003726452,0.08803789,0.00006212277,0.00002689983,0.000003853196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02766955,"threshold_uncertainty_score":0.5781432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05149582325650519,"score_gpt":0.3317676566852545,"score_spread":0.2802718334287493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}