{"id":"W3034606796","doi":"10.1101/2020.06.09.142620","title":"Epigenome-wide change and variation in DNA methylation from birth to late adolescence","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Biotechnology and Biological Sciences Research Council; Economic and Social Research Council; Medical Research Council","keywords":"dNaM; DNA methylation; Epigenome; Biology; CpG site; Epigenetics; Genetics; Genome; Gene; Enhancer; Evolutionary biology; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004328499,0.0001106609,0.0001951454,0.0005286185,0.0001857994,0.000361976,0.0001725286,0.0002467261,0.001270269],"category_scores_gemma":[0.001287009,0.0001320291,0.000276517,0.0006408747,0.0001400356,0.0001698946,0.0003627133,0.0003393298,0.0001107492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001472915,"about_ca_system_score_gemma":0.0001201757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005607053,"about_ca_topic_score_gemma":0.006781907,"domain_scores_codex":[0.999712,0.00008709369,0.00001701127,0.0001097866,0.00003206615,0.00004196421],"domain_scores_gemma":[0.9993659,0.0001913978,0.0001981393,0.0000733282,0.0000952082,0.00007616293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002661673,0.00001493487,0.9832398,0.00002554101,0.0002411593,0.00005086611,0.0001722566,0.0001367094,0.01108199,0.00006978319,0.0001335466,0.004567251],"study_design_scores_gemma":[0.0000013785,0.00002028582,0.999175,0.000002573729,0.0000208012,0.00005012599,0.00004654373,0.00009521917,0.0004101833,0.00002466484,0.0001519207,0.00000128459],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975736,0.0004817915,0.0005885293,0.00003711611,0.000003145799,0.000003439175,0.001036542,0.00001014568,0.0002657383],"genre_scores_gemma":[0.9988831,0.0001411751,0.0003020136,0.0000169901,0.000003122585,0.000005858054,0.0004624085,0.000004850396,0.0001804914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005607053,"threshold_uncertainty_score":0.01114881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343682867864858,"score_gpt":0.2309457852171569,"score_spread":0.2075089565385083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}