{"id":"W3034660339","doi":"10.1002/phar.2438","title":"Baricitinib: A Review of Pharmacology, Safety, and Emerging Clinical Experience in COVID‐19","year":2020,"lang":"en","type":"review","venue":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Sinai Health System","funders":"","keywords":"Medicine; Cytokine release syndrome; Immunology; Proinflammatory cytokine; Tocilizumab; Immune system; Cytokine storm; Janus kinase; Clinical trial; Coronavirus disease 2019 (COVID-19); Cytokine; Inflammation; Disease; T cell; Rheumatoid arthritis; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008057891,0.0005762327,0.001184877,0.001766382,0.0002163905,0.0009412612,0.0006622848,0.0007490041,0.002077127],"category_scores_gemma":[0.001050664,0.0002114896,0.0006675555,0.001509109,0.000301807,0.001220722,0.0004192982,0.001577516,0.0007576964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005309618,"about_ca_system_score_gemma":0.000618251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005353303,"about_ca_topic_score_gemma":0.001300627,"domain_scores_codex":[0.9997737,0.00005304361,0.00005627347,0.00003767131,0.00005909294,0.00002021663],"domain_scores_gemma":[0.9995126,0.0002643873,0.00008963879,0.00000975822,0.00008520257,0.00003851641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003478703,0.0001092276,0.0004441592,0.01791726,0.000156176,0.0003142117,0.00007764672,0.0003702824,0.001722676,0.001808083,0.02351388,0.9532185],"study_design_scores_gemma":[0.0001165008,0.0008781424,0.003543247,0.009931643,0.0006607776,0.00450055,0.0001133432,0.0004181875,0.001215134,0.001591339,0.9769682,0.00006295177],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004720327,0.9981895,0.0001005422,0.000441797,0.0001154365,0.000005457389,0.00002829867,0.000006968115,0.00063995],"genre_scores_gemma":[0.002674931,0.9958743,0.0002133552,0.0004994176,0.0003132296,0.00001054618,0.00007520587,0.0000030599,0.0003357916],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002077127,"threshold_uncertainty_score":0.006948709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1819020636506005,"score_gpt":0.5887281786677656,"score_spread":0.4068261150171651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}