{"id":"W3034683260","doi":"10.1111/cbdd.13743","title":"Novel µ opioid antagonists derived from the µ opioid agonists endomorphin and [Dmt<sup>1</sup>]DALDA (H‐Dmt‐D‐Arg‐Phe‐Lys‐NH<sub>2</sub>)","year":2020,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; Stereochemistry; Agonist; Opioid; Opioid receptor; Antagonist; Opioid peptide; Peptide; Amino acid; Dermorphin; Opioid antagonist; Receptor; Biochemistry; (+)-Naloxone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001968011,0.000646194,0.000801079,0.00003848668,0.0004284591,0.0001294917,0.001170537,0.0003187495,0.00006705202],"category_scores_gemma":[0.001182677,0.0004766115,0.0002208626,0.0003489748,0.001754673,0.0001545634,0.0007402577,0.000902566,0.0002626598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004259527,"about_ca_system_score_gemma":0.0001283999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003713327,"about_ca_topic_score_gemma":0.000001549665,"domain_scores_codex":[0.9959533,0.000507987,0.0006361459,0.001730573,0.0002185313,0.0009534957],"domain_scores_gemma":[0.9960913,0.002573622,0.0002559037,0.0005536302,0.00006329917,0.0004622107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000496764,0.0001263179,0.0002234498,0.00001938652,0.00003398486,0.00005967113,0.0005577242,0.00002405466,0.9920381,0.0004274675,0.00339925,0.002593862],"study_design_scores_gemma":[0.001389535,0.0002513031,0.0002990618,0.00002415808,0.00005496814,0.00006599331,0.00007081294,0.0010581,0.986396,0.001578456,0.008280683,0.0005309559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945052,0.0006384556,0.0007429628,0.002638208,0.0002029713,0.0006515161,0.0002904088,0.0002375956,0.00009266743],"genre_scores_gemma":[0.9814394,0.0009083346,0.000835195,0.01582121,0.0007497647,0.00006840983,0.00008668664,0.00007773776,0.00001329506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.013183,"threshold_uncertainty_score":0.9997686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03660724494420942,"score_gpt":0.23592963635579,"score_spread":0.1993223914115806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}