{"id":"W3034683260","doi":"10.1111/cbdd.13743","title":"Novel µ opioid antagonists derived from the µ opioid agonists endomorphin and [Dmt<sup>1</sup>]DALDA (H‐Dmt‐D‐Arg‐Phe‐Lys‐NH<sub>2</sub>)","year":2020,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; Stereochemistry; Agonist; Opioid; Opioid receptor; Antagonist; Opioid peptide; Peptide; Amino acid; Dermorphin; Opioid antagonist; Receptor; Biochemistry; (+)-Naloxone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008761363,0.0003917244,0.0003818541,0.0001157765,0.0001008673,0.000285859,0.0002917817,0.0002486546,0.0008883592],"category_scores_gemma":[0.00007826799,0.0002005617,0.0001616817,0.00013563,0.000174731,0.0001794794,0.0001878014,0.0005979053,0.0003433167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985192,"about_ca_system_score_gemma":0.0001646476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000291549,"about_ca_topic_score_gemma":0.001009855,"domain_scores_codex":[0.9999363,0.000008149267,0.000004968741,0.00001224075,0.00001820745,0.00002000776],"domain_scores_gemma":[0.9999529,0.000007335207,0.00001529954,0.000002810546,0.000005976091,0.00001566498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001168506,0.00002393439,0.00005627182,0.00003609914,0.000009409115,0.00004300219,0.000008658408,0.0001287676,0.9979621,0.0001125814,0.00003147926,0.001470902],"study_design_scores_gemma":[0.0001616466,0.001858239,0.002288033,0.00001022463,0.000060934,0.0004458888,0.00002898421,0.0009352841,0.9876842,0.00005770469,0.006446547,0.0000221618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901555,0.002484257,0.004173996,0.00007045668,0.0000494664,0.00009870769,0.0004869322,0.0000596591,0.002421189],"genre_scores_gemma":[0.9841282,0.002018602,0.009182868,0.0001551449,0.00002425289,0.0001171366,0.0009784806,0.00002171761,0.003373665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008883592,"threshold_uncertainty_score":0.002971828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03660724494420942,"score_gpt":0.23592963635579,"score_spread":0.1993223914115806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}