{"id":"W3034711420","doi":"10.1158/1055-9965.epi-20-0275","title":"Genome-Wide Gene–Diabetes and Gene–Obesity Interaction Scan in 8,255 Cases and 11,900 Controls from PanScan and PanC4 Consortia","year":2020,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Cancer Council Victoria; Associazione Italiana per la Ricerca sul Cancro; National Health and Medical Research Council; Ministerstvo Zdravotnictví Ceské Republiky; Grantová Agentura České Republiky; European Cooperation in Science and Technology; Khalifa Bin Zayed Al Nahyan Foundation; Society of Memorial Sloan Kettering; Lustgarten Foundation; National Institute of Environmental Health Sciences; Ministerio de Ciencia y Tecnología; Memorial Sloan-Kettering Cancer Center; World Health Organization; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Mayo Clinic; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Gene; Obesity; Diabetes mellitus; Genetics; Genome; Type 2 diabetes; Medicine; Computational biology; Bioinformatics; Biology; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006637688,0.0007971658,0.001508509,0.002179852,0.001519646,0.001375493,0.001006056,0.000999246,0.005838923],"category_scores_gemma":[0.009280675,0.000737118,0.001888977,0.003653792,0.0007700447,0.0003709288,0.001550527,0.0007744211,0.0005578192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005472784,"about_ca_system_score_gemma":0.0009301548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007348665,"about_ca_topic_score_gemma":0.01038517,"domain_scores_codex":[0.9950514,0.001652596,0.000460048,0.001964431,0.0005102374,0.0003613223],"domain_scores_gemma":[0.9960918,0.001488219,0.0006504445,0.001076577,0.0004002548,0.0002926972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005656191,0.0001579565,0.9615974,0.0005075263,0.006565433,0.002117984,0.0006736237,0.0006589122,0.007317934,0.0005509958,0.005591769,0.008604286],"study_design_scores_gemma":[0.0009741017,0.0004422984,0.9822161,0.00008042128,0.004916422,0.001445291,0.0002833622,0.001396329,0.0008462343,0.0003862123,0.006975707,0.00003755684],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785278,0.001805033,0.002877999,0.0002218659,0.00007164237,0.0002256966,0.0143042,0.0001679053,0.00179778],"genre_scores_gemma":[0.9744716,0.0002901205,0.002189935,0.0001439879,0.00004372935,0.0004975976,0.02122778,0.00009181503,0.00104349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007348665,"threshold_uncertainty_score":0.03510392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03172795862000713,"score_gpt":0.3043081222895673,"score_spread":0.2725801636695602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}