{"id":"W3034751517","doi":"10.1038/s41590-020-0697-2","title":"Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms","year":2020,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":287,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institute of Allergy and Infectious Diseases; Wellcome; Medical Research Council; Wellcome Trust; U.S. Department of Health and Human Services; Howard Hughes Medical Institute","keywords":"Pyroptosis; Cell biology; Shigella flexneri; Cytosol; Caspase; Biology; Intracellular parasite; Inflammasome; Intracellular; Signal transduction; Programmed cell death; Apoptosis; Biochemistry; Escherichia coli; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003781832,0.0004008682,0.000198631,0.0002248271,0.0002491178,0.0003619006,0.0002224041,0.0006346052,0.002154256],"category_scores_gemma":[0.0002999359,0.0001878897,0.0003433462,0.00009922074,0.000440292,0.0005296097,0.000606767,0.0009398852,0.0005671732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003947404,"about_ca_system_score_gemma":0.0002331681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002057326,"about_ca_topic_score_gemma":0.0004609916,"domain_scores_codex":[0.9997993,0.00004832011,0.00001364605,0.0000330024,0.00004834431,0.00005738932],"domain_scores_gemma":[0.9998695,0.00002196048,0.00003672516,0.00001804313,0.00001626557,0.00003764106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002250482,0.00002851393,0.0001844733,0.00004208579,0.000007270348,0.0001712338,0.00002534089,0.00005341113,0.9951165,0.001359567,0.0002114697,0.002575141],"study_design_scores_gemma":[0.00009930031,0.00040551,0.006215069,0.00001953915,0.00001500817,0.0006618667,0.00009373122,0.0009643622,0.9813718,0.001816678,0.008322222,0.00001492336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959597,0.01166839,0.01847177,0.002409681,0.0005942663,0.0001564765,0.0005014991,0.000394954,0.006205954],"genre_scores_gemma":[0.981916,0.003300193,0.008317044,0.0004487624,0.00009775001,0.00007068212,0.0003866405,0.00003705773,0.005426024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002154256,"threshold_uncertainty_score":0.007206738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006063131679269652,"score_gpt":0.2245699858239408,"score_spread":0.2185068541446712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}