{"id":"W3034785171","doi":"10.1101/2020.06.12.148957","title":"Single-cell profiling of Ebola virus infection <i>in vivo</i> reveals viral and host transcriptional dynamics","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NHLBI Division of Intramural Research; National Institute of General Medical Sciences; Searle Scholars Program; Life Sciences Research Foundation; Hamilton Health Sciences Foundation; Gilead Sciences; Battelle; Bill and Melinda Gates Foundation; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation; American Society of Tropical Medicine and Hygiene; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Biology; Viral replication; Ebola virus; Virology; Viral pathogenesis; Virus; Immune system; Tropism; Transcriptome; Interferon; Tissue tropism; Gene; Gene expression; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001812462,0.0001464737,0.0003081791,0.0002441411,0.0002222764,0.0005365351,0.0001205837,0.0002571126,0.0007931674],"category_scores_gemma":[0.0001364964,0.00009658851,0.0001670687,0.0002178774,0.000225356,0.0002073099,0.0001842311,0.0004200231,0.0004478592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446001,"about_ca_system_score_gemma":0.000132988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004629254,"about_ca_topic_score_gemma":0.0005743938,"domain_scores_codex":[0.9999025,0.00001014426,0.000004462397,0.0000407396,0.00002336401,0.00001879282],"domain_scores_gemma":[0.999911,0.00002496839,0.00001738594,0.00001158302,0.00001876556,0.00001640277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000411105,0.000007484836,0.001779592,0.00001798732,0.00000409171,0.00001501158,0.00002991232,0.0001067068,0.9968369,0.00005150401,0.00005969962,0.001049937],"study_design_scores_gemma":[0.000006377912,0.0001448812,0.07672274,0.00001241109,0.00002332472,0.0002379981,0.0002379162,0.006439768,0.9119822,0.0004261298,0.003750215,0.00001597394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829585,0.001220035,0.01187943,0.0001172945,0.00002489421,0.00002517171,0.002137923,0.0001308834,0.001505859],"genre_scores_gemma":[0.9813933,0.001109489,0.01188759,0.0001823558,0.00003272466,0.0001037092,0.002658385,0.00007897982,0.002553497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007931674,"threshold_uncertainty_score":0.00265336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02410272428332562,"score_gpt":0.2555101807509946,"score_spread":0.231407456467669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}