{"id":"W3034821185","doi":"10.1038/s41571-020-0401-3","title":"Reply to ‘Personalized treatment of immune-related adverse events — balance is required’","year":2020,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"Microscopic Colitis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Tofacitinib; Medicine; Infliximab; Vedolizumab; Adverse effect; Immune system; Clinical trial; Ulcerative colitis; Internal medicine; Bioinformatics; Immunology; Disease; Rheumatoid arthritis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005879018,0.001386281,0.003504424,0.00179298,0.001436474,0.003746598,0.002389394,0.01849448,0.006376222],"category_scores_gemma":[0.02913501,0.000882727,0.001767335,0.00152173,0.002627538,0.004543536,0.002478452,0.02952705,0.008144206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001597932,"about_ca_system_score_gemma":0.003840513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001740942,"about_ca_topic_score_gemma":0.004020038,"domain_scores_codex":[0.9960063,0.001019599,0.0009122384,0.000520785,0.001155145,0.0003858868],"domain_scores_gemma":[0.9832731,0.008917006,0.001637187,0.0004651044,0.00445771,0.001249921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006360155,0.00001231053,0.0001005939,0.000344692,0.00003928585,0.00009086863,0.00003360261,0.00004211056,0.0001065296,0.0006422321,0.9840051,0.01451912],"study_design_scores_gemma":[0.0001469028,0.00007666427,0.0007529159,0.0007425307,0.00009556904,0.0005427324,0.00009246542,0.0001164697,0.0001383083,0.002817697,0.9944133,0.00006447645],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001287211,0.02723811,0.000336746,0.7590917,0.2119938,0.00002433413,0.0002532707,0.00009604889,0.000837467],"genre_scores_gemma":[0.0008476538,0.0140755,0.0003017042,0.8509449,0.1311499,0.00004255931,0.0001242417,0.00003112429,0.002482394],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01849448,"threshold_uncertainty_score":0.03109157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1337568211477023,"score_gpt":0.5219817870157574,"score_spread":0.388224965868055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}