{"id":"W3034866379","doi":"10.1093/brain/awaa149","title":"TMEM106B, an unexpected point of contact between FTD, ageing and a hypomyelination disorder","year":2020,"lang":"en","type":"letter","venue":"Brain","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Weston Brain Institute; U.S. Department of Defense","keywords":"Frontotemporal dementia; Psychology; Dementia; Neuroscience; Psychiatry; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002922759,0.0009774794,0.00143658,0.0007265623,0.002803456,0.002173127,0.001811851,0.0438572,0.003209149],"category_scores_gemma":[0.01824452,0.0006664149,0.001147449,0.0006593004,0.00215568,0.002461945,0.0009499844,0.02916525,0.005054281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003295593,"about_ca_system_score_gemma":0.002479652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004229675,"about_ca_topic_score_gemma":0.006313129,"domain_scores_codex":[0.9977568,0.0005712859,0.0003540172,0.0004229696,0.0006305492,0.0002645632],"domain_scores_gemma":[0.9939598,0.004146822,0.0003059481,0.0001689546,0.0007960482,0.0006225355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001364935,0.0000285176,0.0003420189,0.00007590339,0.00002087708,0.006360113,0.0001266695,0.00005520447,0.0004273546,0.001610244,0.9814737,0.009342815],"study_design_scores_gemma":[0.0003244161,0.0002647416,0.002827917,0.0004550351,0.00009110627,0.01501395,0.0004078573,0.0009055025,0.0008159181,0.01577171,0.9629911,0.0001307026],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007639882,0.002641999,0.000192048,0.9405758,0.05374948,0.00001616708,0.0001398397,0.0000570148,0.001863713],"genre_scores_gemma":[0.007271159,0.002510293,0.0003331699,0.8499109,0.1332741,0.00005131787,0.00007614947,0.00005022241,0.006522675],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0438572,"threshold_uncertainty_score":0.02391124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120255062950228,"score_gpt":0.2512509611601027,"score_spread":0.2392254548650799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}