{"id":"W3034866379","doi":"10.1093/brain/awaa149","title":"TMEM106B, an unexpected point of contact between FTD, ageing and a hypomyelination disorder","year":2020,"lang":"en","type":"letter","venue":"Brain","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Weston Brain Institute; U.S. Department of Defense","keywords":"Frontotemporal dementia; Psychology; Dementia; Neuroscience; Psychiatry; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005522808,0.0001735174,0.0002160266,0.0000561364,0.00003780086,0.0000245343,0.0001069874,0.0003145478,0.00002769669],"category_scores_gemma":[0.0001728078,0.0001731441,0.00008218033,0.00006498627,0.00004711807,0.000004913507,0.00006178662,0.0001645073,0.000002680451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007431864,"about_ca_system_score_gemma":0.00006096298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003181025,"about_ca_topic_score_gemma":0.00001547276,"domain_scores_codex":[0.9990391,0.0001243309,0.0002264073,0.0003392983,0.0001352086,0.0001356647],"domain_scores_gemma":[0.9994361,0.00002830975,0.0001536159,0.0002356665,0.00006374086,0.00008259474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001097048,0.00004915302,0.007737668,0.0002674735,0.0001988082,0.00009626048,0.0001952505,0.00001203735,0.2664276,0.00003934852,0.7165832,0.008283506],"study_design_scores_gemma":[0.002074971,0.0005536829,0.08143587,0.00006443952,0.0001237151,0.000007268021,0.00009900252,0.0002349502,0.00573142,0.0004025073,0.9086266,0.0006455584],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.545942,0.0008134148,0.001959411,0.4494759,0.00009287395,0.0005300217,0.0003417381,0.0000435959,0.0008009809],"genre_scores_gemma":[0.8448574,0.00002306027,0.0001905354,0.1467526,0.001571879,0.00001503428,0.005898967,0.00004809102,0.0006424515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3027233,"threshold_uncertainty_score":0.7060611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120255062950228,"score_gpt":0.2512509611601027,"score_spread":0.2392254548650799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}