{"id":"W3034914907","doi":"10.1039/d0en00229a","title":"Polyacrylic acid coated nanoparticles elicit endothelial cell apoptosis and diminish vascular relaxation in<i>ex vivo</i>perfused iliac arteries of the cane toad (<i>Rhinella marina</i>)","year":2020,"lang":"en","type":"article","venue":"Environmental Science Nano","topic":"Turtle Biology and Conservation","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; Alberta Hospital Edmonton; University of Calgary; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Company of Biologists; University of Alberta; Alberta Innovates - Health Solutions","keywords":"Ex vivo; Toad; In vivo; Cane; Vascular smooth muscle; Endothelial stem cell; Apoptosis; Anatomy; Chemistry; Materials science; Biology; Medicine; Internal medicine; Smooth muscle; Biochemistry; In vitro; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634329,0.0002751697,0.000130883,0.0001242757,0.0001071339,0.0001945343,0.0001760945,0.0003267537,0.001385341],"category_scores_gemma":[0.00008429783,0.0001931382,0.0002626069,0.00008426617,0.0001967037,0.0001577175,0.0001094638,0.0005149764,0.0002562367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443234,"about_ca_system_score_gemma":0.0001165587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530212,"about_ca_topic_score_gemma":0.001865509,"domain_scores_codex":[0.9999315,0.000008379741,0.000005076568,0.00001903429,0.00001112121,0.00002491781],"domain_scores_gemma":[0.9998978,0.00002354506,0.00002659936,0.00001148662,0.00001456241,0.00002596525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001994307,0.00003061267,0.0001397932,0.0000208372,0.000005233076,0.00004671905,0.00002290226,0.00002574079,0.9990267,0.00003316373,0.00003261718,0.0004162122],"study_design_scores_gemma":[0.00003448116,0.001036772,0.01223356,0.00000823381,0.00004334957,0.0001714264,0.00008792268,0.0005753674,0.9847936,0.00002766167,0.0009820056,0.000005613027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967924,0.0003838846,0.001329626,0.00007735223,0.0000398932,0.00001431762,0.0001284673,0.00004356021,0.001190409],"genre_scores_gemma":[0.9905426,0.0005349503,0.002304985,0.000133707,0.00002436708,0.00004567587,0.0003444553,0.00002087953,0.006048482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530212,"threshold_uncertainty_score":0.00463438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005561900785678887,"score_gpt":0.1701398038334369,"score_spread":0.164577903047758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}